Mitral regurgitation is one of the most common cardiac valve disorders worldwide and the second most frequent indication of cardiac surgery for heart valve disease. During the last decades, open-heart mitral valve repair and replacement have been considered the sole and gold standard invasive therapy for this complex disorder. However, a significant proportion of patients experiences recurrence of mitral regurgitation during long-term follow-up, which entails an important increase in morbidity and mortality. In this scenario, percutaneous therapies to treat mitral regurgitation have become an appealing alternative to conventional surgery given high risk for repeat surgery. The present review describes current evidence of transcatheter mitral valve repair and replacement therapies to treat mitral regurgitation recurrence after surgery.