… additional laboratories using the ACMG-AMP guidelines. Overall concordance across three
laboratories … exist across laboratories, as well as between laboratories and clinical providers. …

… However, they did not provide detailed guidance on how … to variant interpretation discordance
between laboratories. This … benign and known pathogenic variant performance. Similarly, …

… for 20 ACMG/AMP criteria, while nine were deemed not … with representation on our VCEP,
so that laboratory's assertion in … between biocurators using the original ACMG/AMP and the …

… of the ACMG/AMP variant rules by the HL VCEP [5, 9], 157 … Sharing of internal clinical
laboratory case data among members of … to strike a balance between efficiency and leveraging the …

… among clinical laboratories, in particular, allowing for increased visibility of rare … Similarly,
the nine base-pair insertion-deletion polymorphism between the MT-CO2 and MT-TK genes is …

… iterative review and editing between the workgroup and the … Suggestions regarding filtering
relative to variant interpretation … analyzed and classified using the ACMG/AMP standards. …

… changes for nine variants (53%) by ACMG-AMP criteria, of … Differences between original
ACMG-AMP and ClinGen … for use with ACMG/AMP clinical variant interpretation guidelines …

… laboratories do not pay enough attention to updates and do not apply them for variant
interpretation … specifications to the ACMG/AMP variant interpretation guidelines for the PAH gene 1 …

… standards, substantial variability remains among variant curation tools and data sharing by
health care providers, clinical diagnostic laboratories, and … Sequence Variant Interpretation …

… ACMG/AMP guidelines for germline variant interpretation as … In order to identify them,
clinical laboratory geneticists often … evidence to infer variant pathogenicity 9 . Indeed, other …