… (9;22)(q34;q11) rearrangement. The identification of the BCR-… to have evidence of persistent
leukemic cells by DNA PCR. … residual CML LSC may be transcriptionally silent and so not …

… -independent resistance and leukemia stem cell persistence. … ), to increase the transcriptional
activity perturbing the JAK-… from intra-or inter-chromosomal rearrangements and mostly …

… were affected by immunoglobulin rearrangements, whereas rearrangements or deletions in
… PRC-related transcriptional signatures We next characterized the transcriptional changes …

… (TKI) that target the BCR-ABL oncoprotein has led to dramatic … These mechanisms contribute
to the persistence of CML LSCs … The study identified distinct phenotypic and transcriptional …

Chronic myeloid leukemia is a myeloproliferative neoplasm characterized by the presence
of the Philadelphia chromosome and the consequent BCR:: ABL1 oncoprotein. In the era …

… BCR- ABL protein (Figure 1.2). Fifty-five percent (55%) of the b3-a2 transcript and 40% of
the b2- a2 transcript junctions are associated with the 210 kDa BCR::ABL … of rearrangement, …

… MRD is defined as the persistence of leukemic cells after … in B-ALL and T-cell receptor gene
rearrangements in T-ALL, and … whether MRD detected by BCR-ABL qPCR or NGS should …

… This joint pain can be severe and persistent to the point that a small … The existence of this
transcriptionally silent mRNA can … Another possible explanation for BCR::ABL1 persistence …

… caused by the oncogenic BCR-ABL fusion protein in more … The final product of this genetic
rearrangement is a 210-kDa … transcriptional activity, decreased adherence of leukemia cells to …

… Persistence of the LSCs have been postulated to be the … drive expression of their downstream
transcriptional targets [105]. … -associated rearrangements’, involving gene rearrangements …