… leukemia cases, in particular acute myeloid leukemia (AML), … ZNF384-rearranged ALL
displays a unique transcriptional … with aberrant expression of the myeloid markers CD13 and/or …

… Taken for example, the revolutionary drug imatinib has transformed the devastating chronic
myeloid leukaemia (CML) into a chronical manageable disease, yet many patients still …

… gene translocation in chronic myelogenous leukemia (CML) (… to treatments targeting the
rearrangement of interest, had … by approved agents underlines persistence with this approach. …

… like ALK and BCR-ABL[5], while other rearrangements are the … is a monoclonal antibody
to the BCR-ABL fusion product. … Most patients with Hodgkin’s disease present with persistent …

… made between SIRT1 and the BCR-ABL fusion oncogene. … and resulted in polyploidy with
a persistence of the cyclin B/… In DLBCL, MYC and either BCL2 or BCL6 rearrangements are …

… 2, we shall discuss two kinds of chromosomal rearrangement… The same pathways may
activate different transcriptional … of STAT3 and STAT5 in chronic myeloid leukaemia (CML) in …

… , where they persist during the lifetime of the organism. … for leukemia was engineered by
introducing the BCR/ABL … of MLL-rearranged human B cell acute leukemias to reprogramming …

… that can generate genomic rearrangements and challenge cell … of HR, could result in persistent
DSBs that cluster until S-phase to … The fusion oncogene BCR/ABL from the chromosome …

… These studies documented that risk of relapse related to persistent … rearrangements. This
subset was initially recognized by means of gene expression profile, revealing a transcriptional …

… predictor of relapse is the persistence of abnormal cells after … -related leukemias based on
KMT2A rearrangement occur … apparent cause of chronic myelogenous leukemia (reviewed in […