Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues

ACF Lewis, RC Green - Genome Medicine, 2021 - Springer
… The concept of a disease It is part of the hope of precision medicine that disease classification
is refined. In this vision, the broad definitions we have of conditions, based on symptoms …

Precision medicine in diabetes: a consensus report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

WK Chung, K Erion, JC Florez, AT Hattersley… - Diabetes …, 2020 - Am Diabetes Assoc
… of new insights into the phenotype known as “diabetes.” Increased knowledge of this condition
… at risk for reduced life span, amputation, kidney failure, and blindness. A more precise …

Treating systemic lupus erythematosus in the 21st century: new drugs and new perspectives on old drugs

G Ruiz-Irastorza, G Bertsias - Rheumatology, 2020 - academic.oup.com
treatment, glucocorticoids and immunosuppressive drugs. However, these regimens are not
universally effective and a substantial degree of damage … of treatment is individualized but …

Therapeutic approach to Alzheimer's disease: Current treatments and new perspectives

T Pardo-Moreno, A González-Acedo… - Pharmaceutics, 2022 - mdpi.com
… progression of disease symptoms and brain atrophy was also observed compared to the
control group, as well as numerous side effects including skin cancer and renal dysfunction [78]…

Zebrafish models of cancer—new insights on modeling human cancer in a non-mammalian vertebrate

M Hason, P Bartůněk - Genes, 2019 - mdpi.com
… cancer in zebrafish as well as provide new insights on advances in cancer modeling. Recent
… undoubtedly lead to new applications in personalized medicine and combination therapy. …

[HTML][HTML] Review on circular RNAs and new insights into their roles in cancer

X Tang, H Ren, M Guo, J Qian, Y Yang, C Gu - … and structural biotechnology …, 2021 - Elsevier
… Furthermore, future perspectives for the clinical application of circRNAs in the management
of patients with cancer were proposed, which could provide new insights into circRNAs in the …

Therapeutic potential of quercetin: new insights and perspectives for human health

B Salehi, L Machin, L Monzote, J Sharifi-Rad… - ACS …, 2020 - ACS Publications
… as well as its anticancer activity against different cancer cell lines has been recently reported…
a brief overview of the therapeutic effects, new insights, and upcoming perspectives of Que. …

Epigenetics and epigenomics in diabetic kidney disease and metabolic memory

M Kato, R Natarajan - Nature Reviews Nephrology, 2019 - nature.com
… timely diagnosis and prompt treatment to prevent progression to end-stage renal disease. …
wide association studies might also inform precision medicine approaches. Here, we highlight …

New insights into designing hybrid nanoparticles for lung cancer: Diagnosis and treatment

F Mottaghitalab, M Farokhi, Y Fatahi, F Atyabi… - Journal of controlled …, 2019 - Elsevier
… incorporate multiple drugs, targeting agents, and photosensitive reagents opened new
insights into developing more sensitive and specified systems for diagnosis and treatment of lung …

The serendipitous story of SGLT2 inhibitors in heart failure: new insights from DECLARE-TIMI 58

S Verma, JJV McMurray - Circulation, 2019 - Am Heart Assoc
… reduction in hospitalization for heart failure in patients with type 2 diabetes mellitus and
established atherosclerotic vascular disease (ASCVD) who were treated with empagliflozin. Two …