… predict the appropriate dosage required for a given patient. … a CYP3A5 genotype-based TAC
starting dose, with CYP3A5 … authors that renal induction of CYP3A5 and ABCB1 expression …

… risk of tacrolimus-induced nephrotoxicity … personalized dosing strategy improves clinical
outcomes [Citation11]. Therefore, routine use of CYP3A5 genotype to guide tacrolimus dosing …

… on CYP3A5 and PPARA were identified as determining and … and PPARA pre-transplant
genotyping may help to obtain … and therefore helping to maintain suppression of alloimmunity …

… of antithymocyte globulin at first day post-transplantation or basiliximab induction on days 0
… Thus, CYP3A5 genotyping can be helpful in guiding initial TAC dosing in order to achieve …

… dose was defined as the sum of the morning dose, given … , inappropriate dosing of tacrolimus
can also induce kidney injury… tacrolimus metabolism was the recipient's CYP3A5 genotype, …

… been developed to improve personalized tacrolimus treatment. … for dosing tacrolimus, based
on the CYP3A5 genotype [1] … Moreover, although tacrolimus-induced nephrotoxicity is likely …

… (ATG) or basiliximab as induction therapy, followed by Tac … of the alleles CYP3A4*22 and
CYP3A5*1 in the Caucasian … each metaboliser group established according to genotype, we …

… was administered intravenously for induction therapy 4 days after transplanta… CYP3A5
genotyping is useful before transplantation both for selecting the appropriate drug and for dosing…

… Similarly, corticosteroids are known to induce CYP3A enzyme … Given the strong association
found in this study between … of CYP3A5 and CYP3A4 genotypes in Tac initial dose election to …

… need for induction therapy. Clinicians adjusted the TAC daily … difference was found with
regards the CYP3A5 genotyping. … aiming to assist personalized dose adjustment that can …