… Midazolam is one such drug metabolized mainly by hepatic hydroxylation (CYP 3A4) [98]. …
PKPD relationships have been described for IV midazolam in adults. EEG signals that were …

… limit stress from mechanical ventilation in preterm neonates, uncovering numerous dose-limiting …
study focused on the pharmacodynamics of oral sucrose in 245 neonates, performing a …

… and pharmacodynamics (PDs) in prematurely born neonates, … who are substrates for CYP3A4,
such as midazolam. … keto-doxapram in preterm born infants following IV and gastroenteral …

… In preterm and term infants, reliable ability to enterally dose large volumes (>3 ml) are limited,
and if an infant is inpatient and has IV … preterm infants, a sufficient number of infants <28 …

… pain perception and expression were identified in former preterm neonates [5]. Consequently,
… the concept of developmental pharmacology to analgo-sedatives in neonates, this means …

… and cimetidine or ranitidine had no clinically significant effect on the pharmacokinetics and
pharmacodynamics of midazolam. These data indicate that intravenous midazolam can be …

… to 7) in term and late preterm neonates with moderate-to-severe HIE, … iv midazolam,
several sensitivity analyses were conducted to evaluate the possible impact of TH on midazolam …

… While the pharmacodynamics of MDZ in preterm neonates have not been thoroughly
investigated, it is important to note that there is currently no established correlation between MDZ …

… midazolam does not provide analgesia. Additionally, there are concerns regarding the use
of midazolam in preterm infants … , or the delivery room; general pharmacology; comparison of …

… of distribution in preterm infants than in older infants. Preterm infants also have greater …
is 0.8 L/kg, 20 mg/L is the desired concentration, and F for an IV dose is assumed to be 1, a …