Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit
LC Ku, C Simmons, PB Smith… - Journal of Neonatal …, 2019 - content.iospress.com
… midazolam and fentanyl use in term and preterm infants appeared safe and well-tolerated
in this small cohort of infants. … or fentanyl by other routes (eg intravenous). We used clinical …
in this small cohort of infants. … or fentanyl by other routes (eg intravenous). We used clinical …
Preterm physiologically based pharmacokinetic model. Part II: applications of the model to predict drug pharmacokinetics in the preterm population
K Abduljalil, X Pan, A Pansari, M Jamei… - Clinical …, 2020 - Springer
… and pharmacodynamics (including toxicity) in preterm neonates … midazolam concentration–time
profiles in preterm neonates … preterm neonates following a a 15 mg/kg single intravenous …
profiles in preterm neonates … preterm neonates following a a 15 mg/kg single intravenous …
Use of Developmental Midazolam and 1-Hydroxymidazolam Data with Pediatric Physiologically Based Modeling to Assess Cytochrome P450 3A4 and Uridine …
TN Johnson, EM Howgate, SN de Wildt… - Drug Metabolism and …, 2023 - ASPET
… In preterm neonates, overall expression of UGT appeared to be around 10% of that in adults.…
in this study, using an expanded intravenous midazolam dataset in pediatrics, indicated that …
in this study, using an expanded intravenous midazolam dataset in pediatrics, indicated that …
Pharmacokinetics and Pharmacodynamics
AJ Jnah, AP Holmes - Fetal and Neonatal Pharmacology for the …, 2023 - books.google.com
… regimens for term and preterm infants are safe and effective. … superior rectal vein to the
inferior mesenteric vein and portal … Drugs that require CYP3A4 include fentanyl, midazolam, and …
inferior mesenteric vein and portal … Drugs that require CYP3A4 include fentanyl, midazolam, and …
The impact of pharmacogenetics on pharmacokinetics and pharmacodynamics in neonates and infants: a systematic review
N Yalçin, RB Flint, RHN van Schaik… - Pharmacogenomics …, 2022 - Taylor & Francis
… oral pantoprazole (granules) in preterm infants and neonates, … on cyclosporine PK (intravenous
and oral, pre-transplant) in … of 30 neonates and 18 children exposed to midazolam or …
and oral, pre-transplant) in … of 30 neonates and 18 children exposed to midazolam or …
Neonatal pharmacology
BJ Anderson - Anaesthesia & Intensive Care Medicine, 2023 - Elsevier
… useful in very preterm infants, partially useful in older preterm infants, and useful in full-term
infants. … Intravenous bolus of midazolam in neonates has been associated with hypotension; …
infants. … Intravenous bolus of midazolam in neonates has been associated with hypotension; …
Intranasal analgosedation for infants in the neonatal intensive care unit: a systematic review
D Snyers, S Tribolet, V Rigo - Neonatology, 2022 - karger.com
… midazolam … preterm infants, the effectiveness, safety, and pharmacology of IN medications
for acute pain or for sedation, with comparisons with either IV medication or placebo when IV …
for acute pain or for sedation, with comparisons with either IV medication or placebo when IV …
[HTML][HTML] … tool to personalize drug administration in neonates using new techniques: an overview on the pharmacokinetics and pharmacodynamics in neonatal age
DU De Rose, S Cairoli, M Dionisi, A Santisi… - International journal of …, 2020 - mdpi.com
… or extracorporeal life support, preterm infants, infants who need a … Intravenous continuous
infusions may be indicated when … on midazolam (MID) use in spontaneously breathing infants, …
infusions may be indicated when … on midazolam (MID) use in spontaneously breathing infants, …
[HTML][HTML] Physiologically-based pharmacokinetic (PBPK) modeling of buprenorphine in adults, children and preterm neonates
… focus on pharmacokinetic and pharmacodynamic issues [3]. … a whole-body parent-metabolite
intravenous PBPK model of … in the Open Systems Pharmacology (OSP) repository as …
intravenous PBPK model of … in the Open Systems Pharmacology (OSP) repository as …
Pharmacokinetic pharmacodynamic modeling of analgesics and sedatives in children
M Bardol, S Pan, SM Walker, JF Standing… - Pediatric …, 2023 - Wiley Online Library
… Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated
infants … Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexme…
infants … Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexme…