Evaluation of empirical dosing regimens for meropenem in intensive care unit patients using population pharmacokinetic modeling and target attainment analysis
… This highlights the need to develop a robust population PK model for meropenem. In the
present study, we prospectively evaluated meropenem PK and target attainment in a relatively …
present study, we prospectively evaluated meropenem PK and target attainment in a relatively …
Population pharmacokinetics and pharmacodynamics of meropenem in critically ill pediatric patients
J Saito, K Shoji, Y Oho, H Kato… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
… This study investigates the optimal meropenem (MEM) … to assess their probability of target
attainment (PTA) by MIC, which … eGFR formula for Japanese pediatric patients, showed better …
attainment (PTA) by MIC, which … eGFR formula for Japanese pediatric patients, showed better …
Cerebrospinal pharmacokinetic and pharmacodynamic analysis of efficacy of meropenem in paediatric patients with bacterial meningitis
Y Ohata, Y Tomita, K Sunakawa, GL Drusano… - International journal of …, 2019 - Elsevier
… The bactericidal target attainment rates in CSF [50%T >MIC (… or prolonged infusion on target
attainment were investigated. … Japanese guidelines recommend 40 mg/kg q8h meropenem …
attainment were investigated. … Japanese guidelines recommend 40 mg/kg q8h meropenem …
Evaluation of the meropenem dosage and administration schedule in patients with bacteremia initial therapy
T Tai, T Yamamoto, K Yamaguchi, M Watanabe… - Journal of Infection and …, 2023 - Elsevier
… All patients in this study were administered intermittent doses of 30 min. The … of MEPM in
Japanese patients with bacteremia affect pharmacokinetic/pharmacodynamic parameters and …
Japanese patients with bacteremia affect pharmacokinetic/pharmacodynamic parameters and …
Population Pharmacokinetic Modeling of Unbound Meropenem in Patients Undergoing Continuous Renal Replacement Therapy: An Observational Cohort Study
K Oda, H Jono, H Kamohara… - Therapeutic Drug …, 2022 - journals.lww.com
… The analysis was conducted using a Shimadzu (Kyoto, Japan… Dual target achievement
probability simulations were … For the permissive goal of target achievement in the critical …
probability simulations were … For the permissive goal of target achievement in the critical …
[HTML][HTML] … pharmacokinetic modeling and pharmacodynamic target attainment simulation of piperacillin/tazobactam for dosing optimization in late elderly patients with …
N Ishihara, N Nishimura, K Ikawa, F Karino, K Miura… - Antibiotics, 2020 - mdpi.com
… study was to develop a population pharmacokinetic model for piperacillin (PIPC)/tazobactam
(TAZ) in late elderly patients … three times daily to Japanese patients over 75 years old. The …
(TAZ) in late elderly patients … three times daily to Japanese patients over 75 years old. The …
Clinical pharmacokinetic and pharmacodynamic analysis of daptomycin and the necessity of high-dose regimen in Japanese adult patients
T Urakami, Y Hamada, Y Oka, T Okinaka… - Journal of Infection and …, 2019 - Elsevier
… published studies (Phase I study) [5]. Pharmacodynamic variables targeted the ratio of peak
… These parameters allowed for the estimation of the probability of target attainment (PTA) as …
… These parameters allowed for the estimation of the probability of target attainment (PTA) as …
[HTML][HTML] … Target Time above Minimum Inhibitory Concentration Achievement Rate of Meropenem Using Monte Carlo Simulation and In-Hospital Survival in Patients …
H Nakashima, M Miyazaki, T Kuwamura, K Oda… - Antibiotics, 2024 - mdpi.com
… the probability of target attainment (PTA) for each patient, and … probability of target attainment
(PTA) of PK/PD parameters … this clinical study was provided through the website of Japan …
(PTA) of PK/PD parameters … this clinical study was provided through the website of Japan …
Identification of factors affecting meropenem pharmacokinetics in critically ill patients: impact of inflammation on clearance
Y Niibe, T Suzuki, S Yamazaki, M Uchida… - Journal of Infection and …, 2022 - Elsevier
… of this study was to explore factors influencing meropenem … The probability of target attainment
(PTA) predicted by Monte … of Chiba University Hospital (Chiba, Japan). The protocol was …
(PTA) predicted by Monte … of Chiba University Hospital (Chiba, Japan). The protocol was …
Population pharmacokinetic meta-analysis and dosing recommendation for meropenem in critically ill patients receiving continuous renal replacement therapy
Y Peng, Z Cheng, F Xie - Antimicrobial Agents and Chemotherapy, 2022 - Am Soc Microbiol
… on PK/PD probability of target attainment (PTA) is scarcely investigated. Therefore, available
PK/PD analyses are uninformative for guiding meropenem dosing in the CRRT patient …
PK/PD analyses are uninformative for guiding meropenem dosing in the CRRT patient …