First-in-human randomised trial and follow-up study of Plasmodium falciparum blood-stage malaria vaccine BK-SE36 with CpG-ODN (K3)

S Ezoe, NMQ Palacpac, K Tetsutani, K Yamamoto… - Vaccine, 2020 - Elsevier
… 6-20 years-old) in Uganda [7]. In the Uganda follow-up study covering two malaria peak
seasons, encouraging … A phase Ib study in Burkina Faso is now in progress (Pan African Clinical …

[HTML][HTML] Extended follow-up of children in a phase2b trial of the GMZ2 malaria vaccine

S Dassah, B Adu, SB Sirima, B Mordmüller, UA Ngoa… - Vaccine, 2021 - Elsevier
… n = 200) and Uganda (n = 257) were randomized in a 1:1 … trial cohort investigating these
hypotheses may inform improved design of future GMZ2 and other blood stage malaria vaccines

[HTML][HTML] … of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: A phase 1b randomised, controlled, double-blinded, age de-escalation trial

A Ouédraogo, EC Bougouma, NMQ Palacpac… - Frontiers in …, 2023 - frontiersin.org
… /CpG is a recombinant blood-stage malaria vaccine candidate based on … in larger Phase
2/3 trials or with long-term follow-up. … The high baseline antibody titres in Ugandan adults were …

… human malaria infection of healthy adults with lifelong malaria exposure to assess safety, immunogenicity, and efficacy of the asexual blood stage malaria vaccine …

JC Dejon-Agobe, U Ateba-Ngoa… - Clinical Infectious …, 2019 - academic.oup.com
… not develop malaria during follow-upmalaria vaccine with or without a booster dose in
infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

[HTML][HTML] Safety and immunogenicity of BK-SE36 in a blinded, randomized, controlled, age de-escalating phase Ib clinical trial in Burkinabe children

EC Bougouma, NMQ Palacpac, AB Tiono… - Frontiers in …, 2022 - frontiersin.org
… the phase I trial in Uganda justified the conduct of a trial in … trials, BK-SE36 is a promising
blood-stage malaria vaccine … Chitnis) during the trial and follow up study are much appreciated. …

Development of blood stage malaria vaccines

A Vijayan, CE Chitnis - Malaria Control and Elimination, 2019 - Springer
… in the development of malaria vaccines that target the blood stage of malaria parasites. …
Although the Ugandan study was not designed to evaluate efficacy of the vaccine, follow-up of …

[HTML][HTML] Malaria vaccines: progress to date

DI Stanisic, MF Good - BioDrugs, 2023 - Springer
… of blood-stage infection and clinical malaria over 12 months of follow-up with the
acknowledgement that vaccines … This trend was observed in a follow-up study which also reported …

[HTML][HTML] Plasmodium falciparum Blood Stage Antimalarial Vaccines: An Analysis of Ongoing Clinical Trials and New Perspectives Related to Synthetic Vaccines

DR Salamanca, M Gómez, A Camargo… - Frontiers in …, 2019 - frontiersin.org
Phase Ib was developed in two stages in Uganda; the first … An additional randomized,
double-blind, phase Ib study … both trials were related to sample size, short/limited follow-up

[HTML][HTML] Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
stages in the liver, which are not tackled by the blood-stage … month follow-up had an efficacy
of 35% for all malaria events … trials on RTS,S/AS01 vaccine led to a Phase III randomized

[HTML][HTML] Plasmodium falciparum infection coinciding with the malaria vaccine candidate BK-SE36 administration interferes with the immune responses in Burkinabe …

AB Tiono, NMQ Palacpac, EC Bougouma… - Frontiers in …, 2023 - frontiersin.org
… , phase Ib clinical trial with a single-blind follow-up phase … with BK-SE36 blood-stage malaria
vaccine candidate in 12-60 … ) during the trial and follow-up study are much appreciated. We …