First-in-human randomised trial and follow-up study of Plasmodium falciparum blood-stage malaria vaccine BK-SE36 with CpG-ODN (K3)
S Ezoe, NMQ Palacpac, K Tetsutani, K Yamamoto… - Vaccine, 2020 - Elsevier
… 6-20 years-old) in Uganda [7]. In the Uganda follow-up study covering two malaria peak
seasons, encouraging … A phase Ib study in Burkina Faso is now in progress (Pan African Clinical …
seasons, encouraging … A phase Ib study in Burkina Faso is now in progress (Pan African Clinical …
[HTML][HTML] Extended follow-up of children in a phase2b trial of the GMZ2 malaria vaccine
… n = 200) and Uganda (n = 257) were randomized in a 1:1 … trial cohort investigating these
hypotheses may inform improved design of future GMZ2 and other blood stage malaria vaccines…
hypotheses may inform improved design of future GMZ2 and other blood stage malaria vaccines…
[HTML][HTML] … of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: A phase 1b randomised, controlled, double-blinded, age de-escalation trial
A Ouédraogo, EC Bougouma, NMQ Palacpac… - Frontiers in …, 2023 - frontiersin.org
… /CpG is a recombinant blood-stage malaria vaccine candidate based on … in larger Phase
2/3 trials or with long-term follow-up. … The high baseline antibody titres in Ugandan adults were …
2/3 trials or with long-term follow-up. … The high baseline antibody titres in Ugandan adults were …
… human malaria infection of healthy adults with lifelong malaria exposure to assess safety, immunogenicity, and efficacy of the asexual blood stage malaria vaccine …
JC Dejon-Agobe, U Ateba-Ngoa… - Clinical Infectious …, 2019 - academic.oup.com
… not develop malaria during follow-up … malaria vaccine with or without a booster dose in
infants and children in Africa: final results of a phase 3, individually randomised, controlled trial …
infants and children in Africa: final results of a phase 3, individually randomised, controlled trial …
[HTML][HTML] Safety and immunogenicity of BK-SE36 in a blinded, randomized, controlled, age de-escalating phase Ib clinical trial in Burkinabe children
EC Bougouma, NMQ Palacpac, AB Tiono… - Frontiers in …, 2022 - frontiersin.org
… the phase I trial in Uganda justified the conduct of a trial in … trials, BK-SE36 is a promising
blood-stage malaria vaccine … Chitnis) during the trial and follow up study are much appreciated. …
blood-stage malaria vaccine … Chitnis) during the trial and follow up study are much appreciated. …
Development of blood stage malaria vaccines
A Vijayan, CE Chitnis - Malaria Control and Elimination, 2019 - Springer
… in the development of malaria vaccines that target the blood stage of malaria parasites. …
Although the Ugandan study was not designed to evaluate efficacy of the vaccine, follow-up of …
Although the Ugandan study was not designed to evaluate efficacy of the vaccine, follow-up of …
[HTML][HTML] Malaria vaccines: progress to date
DI Stanisic, MF Good - BioDrugs, 2023 - Springer
… of blood-stage infection and clinical malaria over 12 months of follow-up with the
acknowledgement that vaccines … This trend was observed in a follow-up study which also reported …
acknowledgement that vaccines … This trend was observed in a follow-up study which also reported …
[HTML][HTML] Plasmodium falciparum Blood Stage Antimalarial Vaccines: An Analysis of Ongoing Clinical Trials and New Perspectives Related to Synthetic Vaccines
DR Salamanca, M Gómez, A Camargo… - Frontiers in …, 2019 - frontiersin.org
… Phase Ib was developed in two stages in Uganda; the first … An additional randomized,
double-blind, phase Ib study … both trials were related to sample size, short/limited follow-up…
double-blind, phase Ib study … both trials were related to sample size, short/limited follow-up…
[HTML][HTML] Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects
AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
… stages in the liver, which are not tackled by the blood-stage … month follow-up had an efficacy
of 35% for all malaria events … trials on RTS,S/AS01 vaccine led to a Phase III randomized …
of 35% for all malaria events … trials on RTS,S/AS01 vaccine led to a Phase III randomized …
[HTML][HTML] Plasmodium falciparum infection coinciding with the malaria vaccine candidate BK-SE36 administration interferes with the immune responses in Burkinabe …
AB Tiono, NMQ Palacpac, EC Bougouma… - Frontiers in …, 2023 - frontiersin.org
… , phase Ib clinical trial with a single-blind follow-up phase … with BK-SE36 blood-stage malaria
vaccine candidate in 12-60 … ) during the trial and follow-up study are much appreciated. We …
vaccine candidate in 12-60 … ) during the trial and follow-up study are much appreciated. We …