[HTML][HTML] Perioperative cetuximab with cisplatin and 5-fluorouracil in esogastric adenocarcinoma: a phase II study

C Gronnier, C Mariette, C Lepage, C Monterymard… - Cancers, 2023 - mdpi.com
… A phase I/II trial evaluating two cycles of induction cetuximab … and cetuximab) and a phase
II trial evaluating two weekly doses … Conversely, the combination of cetuximab with irinotecan, …

[HTML][HTML] Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer (ESWN 01): a prospective randomized …

J Huang, B Xu, Y Liu, J Huang, P Lu, Y Ba, L Wu… - Cancer …, 2019 - Springer
… in the gefitinib arm, is the largest randomized phase 3 trial performed for esophageal
cancer patients whose disease progressed after chemotherapy. In that study, the gefitinib arm …

A phase II randomized trial of panitumumab, erlotinib, and gemcitabine versus erlotinib and gemcitabine in patients with untreated, metastatic pancreatic …

TR Halfdanarson, NR Foster, GP Kim, JP Meyers… - The …, 2019 - academic.oup.com
patients with advanced adenocarcinoma of the pancreas. Gemcitabine was shown to be
superior to 5fluorouracil … when oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX…

… Study of Preoperative Chemoradiotherapy with Oxaliplatin, Infusional 5Fluorouracil, and Cetuximab Followed by Postoperative Docetaxel and Cetuximab in Patients …

MK Gibson, P Catalano, LR Kleinberg… - The …, 2020 - academic.oup.com
… , including the small molecules gefitinib and erlotinib as well … patient predecessor trial, ECOG
1201, that gave neoadjuvant chemoradiotherapy along with paclitaxel/cisplatin or irinotecan

A phase II study alternating erlotinib with second-line mFOLFOX6 or FOLFIRI for metastatic colorectal cancer

MR Kearney, EY Chen, GM Vaccaro… - Anticancer …, 2019 - ar.iiarjournals.org
… , 5-fluorouracil and leucovorin (FOLFOX) or irinotecan, … in metastatic colorectal cancer
than erlotinib and gefitinib, as … infusional 5-fluorouracil, leucovorin, and oxaliplatin in patients

[HTML][HTML] Targeted therapy for cancers: from ongoing clinical trials to FDA-approved drugs

HY Choi, JE Chang - International Journal of Molecular Sciences, 2023 - mdpi.com
… adenocarcinoma patients who exhibit resistance to gefitinib or … phase III VELOUR study,
the FDA approved ziv-aflibercept, in combination with 5-fluorouracil, leucovorin, and irinotecan

[PDF][PDF] Observation of efficacy and prognosis of chemoradiotherapy with apatinib in combination with oxaliplatin 5-fluorouracil leucovorin in the gastric cancer in …

R Zhang, S Cao, X Yu, D Zhang, S Cui, C Liu… - International Journal of …, 2021 - sid.ir
… Conclusion: our study showed that apatinib combination with oxaliplatin+ 5-fluorouracil+
leucovorin seems to have promising efficacy, and is worthy of being studied as a new regimen …

Fruquintinib: a novel antivascular endothelial growth factor receptor tyrosine kinase inhibitor for the treatment of metastatic colorectal cancer

Y Zhang, JY Zou, Z Wang, Y Wang - Cancer Management and …, 2019 - Taylor & Francis
5-fluorouracil, oxaliplatin and irinotecan. … phase II trial (NCT02976116) to evaluate the
efficacy and safety of fruquintinib in combination with gefitinib, for the first-line treatment in patients

[HTML][HTML] PANTHER: AZD8931, inhibitor of EGFR, ERBB2 and ERBB3 signalling, combined with FOLFIRI: a Phase I/II study to determine the importance of schedule …

DJ Propper, F Gao, MP Saunders, D Sarker… - British journal of …, 2023 - nature.com
Gefitinib induces a cell cycle arrest in G1 phase with chronic administration and … S phase
such as irinotecan. For example, in a preclinical study in breast cancer of the effects of gefitinib, …

A review on emerging targeted therapies for the management of metastatic colorectal cancers

R Deshmukh, M Prajapati, RK Harwansh - Medical Oncology, 2023 - Springer
… efficacy against colorectal cancer was 5-fluorouracil [11]. … with bolus 5-FU (irinotecan, bolus
5-FU, and leucovorin [IFL]), … The most significant inhibitors of EGRF are erlotinib and gefitinib (…