High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer: an open-label, randomised, phase 2 trial

BH Grønberg, KT Killingberg, Ø Fløtten… - The Lancet …, 2021 - thelancet.com
… first randomised trial comparing high-dose, twice-daily thoracic radiotherapyphase II trial
comparing twice daily hyperfractionated with once daily hypofractionated thoracic radiotherapy

Once daily (OD) versus twice-daily (BID) chemoradiation for limited stage small cell lung cancer (LS-SCLC): A meta-analysis of randomized clinical trials

GA Viani, AG Gouveia, FK Matsuura, AA Jacinto… - Radiotherapy and …, 2022 - Elsevier
… of chemotherapy until the completion of RT is maintained [17]. Recently, a small, phase 2
randomized trial comparing … on phase II randomized trials, and further randomized phase III are …

[HTML][HTML] … efficacy and toxicity of twice-daily vs. once-daily concurrent chemoradiotherapy for limited-stage small cell lung cancer based on randomized controlled trials

Q Wu, Y Xiong, S Zhang, X Chen, F Yi, Y Wei… - Frontiers in …, 2020 - frontiersin.org
… The latest large phase III randomized controlled trial (RCT) has … Four studies compared OS
in the two arms and included … future studies should use advanced radiotherapy techniques to …

[HTML][HTML] Treatment outcomes of older participants in a randomized trial comparing two schedules of twice-daily thoracic radiotherapy in limited-stage SCLC

KT Killingberg, BH Grønberg, M Slaaen… - Journal of Thoracic …, 2023 - Elsevier
… We conducted a randomized phase II trial comparing twice-daily TRT of 45 Gy in 30 … years
old or older were able to complete chemotherapy and twice-daily TRT, overall and in the high-…

[HTML][HTML] … related quality of life from a randomized phase II trial comparing standard-dose with high-dose twice daily thoracic radiotherapy in limited stage small-cell lung …

KT Killingberg, TO Halvorsen, Ø Fløtten, OT Brustugun… - Lung Cancer, 2022 - Elsevier
… 60 Gy concurrently with cisplatin/etoposide chemotherapy. The 150 patients who commenced
… randomized phase II trial by our group, we compared hypo-fractionated once-daily TRT of …

[HTML][HTML] … of Radiation Therapy Treatment Plans in a Randomized Phase 2 Trial Comparing 2 Schedules of Twice-Daily Thoracic Radiation Therapy in Limited Stage …

N Levin, KT Killingberg, TO Halvorsen… - International Journal of …, 2024 - Elsevier
… thoracic radiation therapy (TRT) concurrently with chemotherapy in limited-stage small
cell … 1.5 Gy was, for some patients, substituted with once-daily 2.8 Gy for a few fractions as …

High-dose once-daily thoracic radiotherapy in limited-stage small-cell lung cancer: CALGB 30610 (Alliance)/RTOG 0538

J Bogart, X Wang, G Masters, J Gao… - Journal of Clinical …, 2023 - ascopubs.org
… to 45-Gy twice-daily (n = 313) or 70-Gy once-daily radiotherapy (n = … Two additional large
multi-institutional phase III trials testing … trial compared 66-Gy once-daily with 45-Gy twice-daily

… -a-day radiation plus fluorouracil/cisplatin or once daily radiation plus gemcitabine for muscle-invasive bladder cancer: NRG/RTOG 0712—a randomized phase II trial

JJ Coen, P Zhang, PJ Saylor, CT Lee, CL Wu… - Journal of Clinical …, 2019 - ascopubs.org
… Patients were stratified by clinical T stage (T2 v T3-4a); using … In our study, as the two arms
had differing chemotherapy … et al: Phase I study of gemcitabine and radiotherapy plus cisplatin …

Hypofractionated vs. Twice Daily Radiotherapy for Limited Stage Small-Cell Lung Cancer: A Propensity Score-Matched Analysis

L Zhao, W Zhou, Y Yin, M Shi - International Journal of Radiation …, 2021 - redjournal.org
… LU005 is a randomized phase II/III trial designed to test the addition of atezolizumab …
chemotherapy in both treatment arms. Stratification variables include radiation schedule (once daily

[HTML][HTML] Long-term outcomes after concurrent once-or twice-daily chemoradiation in limited-stage small-cell lung cancer: a brief report from the CONVERT trial

GM Walls, H Mistry, F Barlesi, A Bezjak… - International Journal of …, 2024 - Elsevier
… was a phase 3 international randomized clinical trial comparing once-daily (OD) and
twice-daily (BD) radiation therapy (RT). … In addition, a Chinese phase II study testing moderately …