Immunological monitoring in hepatitis C virus controlled human infection model

NH Shoukry, AL Cox, CM Walker - Clinical Infectious Diseases, 2023 - academic.oup.com
T cells in the liver may also exhibit phenotypic and functional … + T cells are required for
protection from persistent hepatitis CIntrahepatic CD8+ T-cell failure during chronic hepatitis C

Lymphocyte Landscape after Chronic Hepatitis C Virus (HCV) Cure: The New Normal

A Ghosh, S Romani, S Kottilil, B Poonia - International Journal of …, 2020 - mdpi.com
… 10% of peripheral T cells and about 12–50% of T cells in the … persisting dysfunctional
phenotype and functional state in a … A skewing of intrahepatic T cells towards a higher Th17/FoxP3 …

[HTML][HTML] Long-Lasting Virus-Specific T Cell Response with Divergent Features in Self-Resolved and Chronic Hepatitis C Virus Patients 35 Years Postinfection

W Ji, M Zhao, J Zhou, H Zheng, N Li, B Han, W Yin… - …, 2022 - journals.aai.org
… This failure of intrahepatic virus-specific CD8 + T cells to sufficiently control the virus
occurs … To investigate the memory phenotype of T cells, we analyzed PBMCs based on the …

A juggernaut of innate & adaptive immune cells in chronic hepatitis C

S Tomer, SK Arora - Indian Journal of Medical Research, 2020 - journals.lww.com
… immune cells such as NK cells, B cells, DCs and T cells in … The mDC are phenotypically
positive for BDCA1 and are the … the functional status of myeloid DCs, as it was shown that the …

Direct-acting antiviral treatment downregulates immune checkpoint inhibitor expression in patients with chronic hepatitis C

L Szereday, M Meggyes, T Berki, A Miseta… - Clinical and …, 2020 - Springer
T cells and increases NK cell cytotoxicity against T helper … activation of intrahepatic and
blood innate immune cells, … on the analysis of phenotype distribution and different immune …

Effects of hepatitis B surface antigen on virus-specific and global T cells in patients with chronic hepatitis B virus infection

N Le Bert, US Gill, M Hong, K Kunasegaran, DZM Tan… - Gastroenterology, 2020 - Elsevier
… All patients included were hepatitis C virus, hepatitis D virus, … and CD8 T cells of naive,
memory, and effector phenotypes; … the quantity of intrahepatic lymphocytes necessary for such …

Liver-resident bystander CD8+ T cells contribute to liver disease pathogenesis in chronic hepatitis D virus infection

…, D Kapuria, FJ Bolte, DE Kleiner, C Koh, T Heller… - Gastroenterology, 2021 - Elsevier
chronic HBV and 55% of patients with chronic hepatitis C … we analyzed the phenotype of
HDV-specific CD8 + T cells in … The characterization of intrahepatic CD8 + T cells was the main …

Diverse facets of MDSC in different phases of chronic HBV infection: Impact on HBV‐specific Tcell response and homing

S Pal, D Dey, BC Chakraborty, M Nandi, M Khatun… - …, 2022 - Wiley Online Library
… A diversity was noted in the functional state of MDSCs across … The intrahepatic MDSCs of
patients with CHB were also found … Our results highlighted that the phenotypic and functional

Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8+ T cells

…, L Hannibal, C Neumann-Haefelin, T Boettler… - Gut, 2023 - gut.bmj.com
… murine intrahepatic HBV-specific CD8 + T cells in chronic but … cHBV, chronic hepatitis B
virus; cHCV, chronic hepatitis CT cell phenotype with the clinical activity in chronic HBV and …

Activated γδ T cells exhibit cytotoxicity and the capacity for viral clearance in patients with acute hepatitis B

ZH Jia, YY Li, JY Wang, JY Zhang, A Huang, XD Guo… - Clinical …, 2019 - Elsevier
Phenotype and function of γδ T cells were analyzed in 29 AHB … capacity of these cells in
CHB and chronic hepatitis C (CHC) … Thirdly, although intrahepatic distribution of γδ T cells was …