AKT as a therapeutic target for cancer

M Song, AM Bode, Z Dong, MH Lee - Cancer research, 2019 - AACR
… epithelium and increased apoptosis but did not alter 15-PGDH protein expression 2007 …
the overexpression of phosphorylated AKT an insignificant independent prognostic marker …

Targeting AKT/PKB to improve treatment outcomes for solid tumors

M Iida, PM Harari, DL Wheeler, M Toulany - … Research/Fundamental and …, 2020 - Elsevier
… It has been reported that pAKT overexpression is a negative prognostic factor for breast …
pAKT expression was significantly correlated with HER2 overexpression (p < 0.001). Another …

Interfering with the ubiquitin-mediated regulation of Akt as a strategy for cancer treatment

E Paccosi, A Balzerano… - International Journal of …, 2023 - mdpi.com
… of human cancers, its overexpression or abnormal activation … roles of Akt in human cancer
will be discussed, with a main … significantly related to a poor prognosis compared with the low …

PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer

X Li, C Li, C Guo, Q Zhao, J Cao, HY Huang… - Journal of Genetics and …, 2021 - Elsevier
… heterogeneous disease with an extremely poor prognosis, which is mainly attributed to the
phospho-AKT, phospho-mTOR and phospho-S6 levels after EGFR overexpression (Fig. 5E)…

The relation between PI3K/AKT signalling pathway and cancer

S Noorolyai, N Shajari, E Baghbani, S Sadreddini… - Gene, 2019 - Elsevier
… an insertion into the sequence that alter the reading frame and … not renovated by AKT1
overexpression. Furthermore, studies in … Moreover, accumulated expression of phospho-AKT has …

Alkaloid-Based Modulators of the PI3K/Akt/mTOR Pathway for Cancer Therapy: Understandings from Pharmacological Point of View

F Mokhfi, M Al Amin, M Zehravi, SH Sweilam… - … -Biological Interactions, 2024 - Elsevier
… treatments often demonstrates synergistic effects, emphasizing … homolog, amplification or
overexpression of Akt or mTOR, and … This assists in predicting the prognosis of metastatic CRC …

Akt: a key transducer in cancer

PJ Tsai, YH Lai, RK Manne, YS Tsai… - Journal of biomedical …, 2022 - Springer
… Of note, overexpression of specific Akt isoforms has been … , have also been reported to
alter Akt kinase activity and/or … , which serves as a poor prognosis marker in non-small cell …

Comparing PI3K/Akt inhibitors used in ovarian cancer treatment

YH Wu, YF Huang, CC Chen, CY Huang… - Frontiers in …, 2020 - frontiersin.org
… with tumor p-Akt (S473) overexpression, but not p-Akt (T308) … (T308), should be used as
a prognostic biomarker in EOC. … inhibitors could not inhibit COL11A1 and PDK1 should alter

Effect of AKT1 (p. E17K) hotspot mutation on malignant tumorigenesis and prognosis

Y Chen, L Huang, Y Dong, C Tao, R Zhang… - Frontiers in Cell and …, 2020 - frontiersin.org
… mutations alter DNA double strand break repair and radiosensitivity” by S. Oeck, used under
… to important cellular alterations through synergistic other oncogenic signaling cascade …

Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer

M Mortazavi, F Moosavi, M Martini, E Giovannetti… - Critical reviews in …, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …