AKT as a therapeutic target for cancer
… epithelium and increased apoptosis but did not alter 15-PGDH protein expression 2007 …
the overexpression of phosphorylated AKT an insignificant independent prognostic marker …
the overexpression of phosphorylated AKT an insignificant independent prognostic marker …
Targeting AKT/PKB to improve treatment outcomes for solid tumors
… It has been reported that pAKT overexpression is a negative prognostic factor for breast …
pAKT expression was significantly correlated with HER2 overexpression (p < 0.001). Another …
pAKT expression was significantly correlated with HER2 overexpression (p < 0.001). Another …
Interfering with the ubiquitin-mediated regulation of Akt as a strategy for cancer treatment
E Paccosi, A Balzerano… - International Journal of …, 2023 - mdpi.com
… of human cancers, its overexpression or abnormal activation … roles of Akt in human cancer
will be discussed, with a main … significantly related to a poor prognosis compared with the low …
will be discussed, with a main … significantly related to a poor prognosis compared with the low …
PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer
X Li, C Li, C Guo, Q Zhao, J Cao, HY Huang… - Journal of Genetics and …, 2021 - Elsevier
… heterogeneous disease with an extremely poor prognosis, which is mainly attributed to the
… phospho-AKT, phospho-mTOR and phospho-S6 levels after EGFR overexpression (Fig. 5E)…
… phospho-AKT, phospho-mTOR and phospho-S6 levels after EGFR overexpression (Fig. 5E)…
The relation between PI3K/AKT signalling pathway and cancer
… an insertion into the sequence that alter the reading frame and … not renovated by AKT1
overexpression. Furthermore, studies in … Moreover, accumulated expression of phospho-AKT has …
overexpression. Furthermore, studies in … Moreover, accumulated expression of phospho-AKT has …
Alkaloid-Based Modulators of the PI3K/Akt/mTOR Pathway for Cancer Therapy: Understandings from Pharmacological Point of View
F Mokhfi, M Al Amin, M Zehravi, SH Sweilam… - … -Biological Interactions, 2024 - Elsevier
… treatments often demonstrates synergistic effects, emphasizing … homolog, amplification or
overexpression of Akt or mTOR, and … This assists in predicting the prognosis of metastatic CRC …
overexpression of Akt or mTOR, and … This assists in predicting the prognosis of metastatic CRC …
Akt: a key transducer in cancer
… Of note, overexpression of specific Akt isoforms has been … , have also been reported to
alter Akt kinase activity and/or … , which serves as a poor prognosis marker in non-small cell …
alter Akt kinase activity and/or … , which serves as a poor prognosis marker in non-small cell …
Comparing PI3K/Akt inhibitors used in ovarian cancer treatment
… with tumor p-Akt (S473) overexpression, but not p-Akt (T308) … (T308), should be used as
a prognostic biomarker in EOC. … inhibitors could not inhibit COL11A1 and PDK1 should alter …
a prognostic biomarker in EOC. … inhibitors could not inhibit COL11A1 and PDK1 should alter …
Effect of AKT1 (p. E17K) hotspot mutation on malignant tumorigenesis and prognosis
Y Chen, L Huang, Y Dong, C Tao, R Zhang… - Frontiers in Cell and …, 2020 - frontiersin.org
… mutations alter DNA double strand break repair and radiosensitivity” by S. Oeck, used under
… to important cellular alterations through synergistic other oncogenic signaling cascade …
… to important cellular alterations through synergistic other oncogenic signaling cascade …
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …