The rs2601796 variant in ADCY9 gene is associated with severe asthma and less bronchodilator response

HMP Teixeira, ÁA Cruz, TS Jesus, MBR de Santana… - Gene, 2023 - Elsevier
… Severe asthma patients require treatment with high dose of inhaled … Short-acting
bronchodilators were withheld 6 h prior to … Genetic polymorphisms of the beta-2 andrenergic …

Phosphodiesterase 4B inhibition: a potential novel strategy for treating pulmonary fibrosis

M Kolb, B Crestani, TM Maher - European Respiratory Review, 2023 - Eur Respiratory Soc
… sclerosis (SSc)-associated ILD and other chronic fibrosing … stroke [30] and response to
short-acting bronchodilators [31]. … -induced late-asthmatic response and reduced biomarkers of …

Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study

J Yee, HS Hwang, JE Chung, JY Park, KE Lee… - European Journal of …, 2019 - Springer
… PDE4A, 4B, 4C, and 4D mRNA subtypes are present in human … genetic variations and β
agonists among asthma patients by … , showed significant associations with responsiveness of β2 …

Rhinovirus C15 attenuates relaxation and cAMP production in human airways and smooth muscle

EB Gebski, V Parikh, H Lam, N Kim… - American journal of …, 2023 - atsjournals.org
… Additionally, we show that Iso (a short-acting β 2 AR agonist), … study of pediatric patients
with asthma found that the children … Here we sought to examine responses to bronchodilators

SNPs, adipokynes and adiposity in children with asthma

ME Machado, LC Porto, MG Alves Galvão… - … of Asthma, 2023 - Taylor & Francis
… of genetic polymorphisms and adipokines effects in children … pathway, which further
responds by releasing anorexigenic … were not associated with asthma in children (Citation21). …

Pharmacology of the Airways

C Bailey, PJ Wojciechowski, WE Hurford - Principles and Practice of …, 2019 - Springer
… beta-2 adrenergic agonists are administered for the acute relief … beta-2 agonists for asthmatic
patients that are poorly controlled … of more potent bronchodilators such as short-acting beta-…

[HTML][HTML] Phosphodiesterases as therapeutic targets for respiratory diseases

H Zuo, I Cattani-Cavalieri, N Musheshe… - Pharmacology & …, 2019 - Elsevier
… selective PDE inhibitors in the treatment of COPD and asthma. … relies mainly on the use of
bronchodilators (β 2 -adrenoceptor (… the role of PDE3 in an acute house dust mite-driven (HDM-…

Severe asthma

R Wong, FA Maffei - Pediatric Critical Care: Text and Study Guide, 2021 - Springer
… 17q21 strongly associated with childhood-onset asthma. Variation … to repetitive or continuous
administration of short-acting … evaluating levalbuterol and albuterol for acute asthma in all …

Asthma pharmacotherapy: an update on leukotriene treatments

HKT Trinh, SH Lee, TBT Cao… - Expert review of respiratory …, 2019 - Taylor & Francis
… Involvement of LTs C 4 /D 4 /E 4 has been demonstrated in … symptoms, and reduction in
short-acting β-agonist (SABA) use in … and the efficacy of bronchodilator is controversial; however, …

Respiratory Disorders of the Immune System and Their Pharmacological Treatment

CB Mathias - Pharmacology of Immunotherapeutic Drugs, 2020 - Springer
… , some patients have intrinsic asthma, which is not associated … While short-acting β 2 -agonists
such as albuterol are frequently … In patients with acute severe asthma, it is effective when …