… that are involved in Ca2+ 434 regulation, including histidine-rich Ca2+-binding protein (HRC), …
FAM20C can phosphorylate calcium-binding protein 45 kDa and then regulate its 485 …

… of common clinical variants of the histidine-rich Ca2+-binding protein (HRC) in human …
FAM20C in these is on its ability to phosphorylate members of the secretory calcium-binding …

… make FAM20C an important protein kinase. At the physiological and pathological level,
FAM20C gene mutations or aberrant function of kinase … that FAM20C could phosphorylate ER …

… indicates that Fam20C-dependent phosphorylation is more … have established Fam20C as
a major protein kinase. Here, we … Histidine-rich calcium binding protein (HRC) was the first …

… domain tail, which is a phosphorylation site for FAM20C and casein kinase 2 (CK2) [113]. Its
… histidine-rich calcium-binding protein (HRC) was the first SR protein involved with FAM20C. …

… length Fam20C with basal activity can phosphorylate specific … fully active mature Fam20C
phosphorylates substrates more … a calcium-binding protein (56), autophosphorylated Fam20C …

… lack of FAM20C phosphorylation of histidine-rich calcium binding protein causes ventricular
… Furthermore, we demonstrate for the first time that the expression of the FAM20C kinase is …

… kinases phosphorylate either protein or sugar substrates. Of these, Fam20C was shown
to be the authentic Golgi casein kinase, … of Fam20C in mammals has focused on calcium-binding …

… of the FAM20C gene that encodes a kinase that phosphorylates most of … histidine rich calcium
binding protein (HRC), calreticulin and calsequestrin-2 are phosphorylated by FAM20C 24,…

… The human genetic variant of HRC, rs3745297 (Ser96Ala), is a famous SNP that results in
the abolishment of the HRC phosphorylation site by Fam20C kinase and dysregulation of the …