Pigment EpitheliumDerived Factor Protects Retinal Neural Cells and Prevents Pathological Angiogenesis in an Ex Vivo Ischemia Model

L Xi, M Tikhonovich, A Biesemeier… - Oxidative Medicine …, 2022 - Wiley Online Library
… We showed that a single intravitreal PEDF injection inhibits … a VEGF antagonist inhibits
neovascularization and prevents … induced, resembling ischemia-induced morphological changes …

[HTML][HTML] Combination of pigment epithelium derived factor with anti-vascular endothelial growth factor therapy protects the neuroretina from ischemic damage

L Xi - Biomedicine & Pharmacotherapy, 2022 - Elsevier
… effects and suppression of physiological revascularization. … the treatment of ischemia-induced
retinal neurodegeneration. … effective on ischemia-induced retinal neovascularization. The …

Pigment epitheliumderived factor as a possible treatment agent for choroidal neovascularization

L Xi - Oxidative medicine and cellular longevity, 2020 - Wiley Online Library
… -induced neovascularization, and mice with ischemia-induced retinal neovascularization. …
, and whether it can suppress inflammation occurring in the retina and reduce macrophage …

[HTML][HTML] Pigment epithelium-derived factor and its role in microvascular-related diseases

Y Wang, X Liu, X Quan, X Qin, Y Zhou, Z Liu, Z Chao… - Biochimie, 2022 - Elsevier
Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor … as a
potentially neurodifferentiation-active factor in fetal retinal pigment epithelium (RPE) cells [10]. …

Pigment epithelium-derived factor (PEDF) alone or in combination with an anti-VEGF drug as a possible treatment of choroidal neovascularization and ischemic ocular …

L Xi - 2024 - ub01.uni-tuebingen.de
… does not always successfully suppress CNV, and no … ischemia-induced retinal
neovascularization rat model, there was an increased VEGF level and decreased PEDF level in the

Combination of Pigment Epithelium Derived Factor (PEDF) With Anti-Vascular Endothelial Growth Factor (VEGF) Therapy Protects the Retina From Ischemic Damage

L Xi - 2021 - researchsquare.com
… VEGF and reversing neovascularization, it also inhibits physiological revascularization [4, 5,
… may be more effective on ischemiainduced retinal neovascularization. The results provide …

The role of pigment epithelium-derived factor in protecting against cellular stress

N Brook, E Brook, A Dharmarajan, A Chan… - Free Radical …, 2019 - Taylor & Francis
factor in retinal pigmented epithelium cells in the late 1980s, there has been an increase in
understanding of the role that pigment epithelium-derived factor (… retinal neovascularization in …

Therapeutic potential of pigment epithelium-derived factor in cancer

S Yamagishi, Y Koga, A Sotokawauchi… - Current …, 2019 - ingentaconnect.com
… A PEDF-derived peptide inhibits retinal neovascularization and blocks mobilization of
bone marrow-derived endothelial progenitor cells. Exp Diabetes Res 2012; 2012: 518426. …

Pigment Epithelium-Derived Factor Improves Paracellular Blood–Brain Barrier Integrity in the Normal and Ischemic Mouse Brain

A Riabinska, M Zille, MY Terzi, R Cordell… - Cellular and molecular …, 2020 - Springer
… In this study, we investigated (a) whether PEDF inhibits VEGF-induced pathologic BBB
disruption in the mouse brain, (b) the time course and route of BBB permeability as well as the …

[HTML][HTML] Autophagy: a new mechanism for regulating VEGF and PEDF expression in retinal pigment epithelium cells

R Li, JH Du, GM Yao, Y Yao, J Zhang - International Journal of …, 2019 - ncbi.nlm.nih.gov
Retinal pigment epithelium (RPE) cells secrete a variety of … growth factor (VEGF) and pigment
epithelium derived factor (… roles of autophagy of RPE cells in retinal neovascularization. …