[HTML][HTML] Neovascular macular degeneration: a review of etiology, risk factors, and recent advances in research and therapy

A Pugazhendhi, M Hubbell, P Jairam… - International Journal of …, 2021 - mdpi.com
… downstream pathways that suppress vascular permeability … competes with Ang1 to suppress
phosphorylation and leads … of PEDF [185] (pigment epithelium-derived factor) via the RPE […

Pathophysiology of neovascular glaucoma

Q Wang, TV Johnson - Neovascular Glaucoma: Current Concepts in …, 2022 - Springer
… of VEGF signaling by suppressing growth factor production. … shown to play a role in
ischemia-induced retinopathy [36]. … among them being pigment epithelium-derived factor (PEDF) …

[图书][B] Interleukin 35 Inhibits Ischemia-Induced Angiogenesis Essentially through the Key Receptor Subunit Interleukin 12 Receptor Beta 2

H Fu - 2019 - search.proquest.com
inhibits HMVEC migration in wound healing assay in vitro … proteins including pigment
epithelium-derived factor (PEDF), serpin … The retina vascularization occurs in the first 2 weeks after …

Novel anti-angiogenic PEDF-derived small peptides mitigate choroidal neovascularization

N Sheibani, S Wang, SR Darjatmoko, DL Fisk… - Experimental eye …, 2019 - Elsevier
neovascular retinopathies. While anti-VEGF treatment slows progression, pathology is often
supported by decrease in intraocular pigment epithelium-derived factor (… neovascular retina

[HTML][HTML] Changes in plasma VEGF and PEDF levels in patients with central serous chorioretinopathy

M Chrząszcz, W Pociej-Marciak, K Żuber-Łaskawiec… - Medicina, 2021 - mdpi.com
… growth factor (VEGF) and pigment-epitheliumderived factor (… It also inhibits angiogenesis
and elevated vascular … further participate in the formation of retinal neovascularization [7,25]. …

Protective effects of dexamethasone on hypoxia-induced retinal edema in a mouse model

M Inada, M Taguchi, K Harimoto, Y Karasawa… - Experimental eye …, 2019 - Elsevier
… Dexamethasone prevented up-regulation of the cytokines and suppressed retinal edema. …
We therefore investigated whether dexamethasone suppresses the hypoxia-induced edema in …

Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology

ML Formica, HG Awde Alfonso… - Pharmacology Research …, 2021 - Wiley Online Library
suppression of subretinal and retinal neovascularization in … Other small peptides based
on pigment epithelium-derived (… and ischemia-induced retinal neovascularization in a mice …

Tissue-targeted and localized AAV5-DCN and AAV5-PEDF combination gene therapy abrogates corneal fibrosis and concurrent neovascularization in rabbit eyes in …

RR Mohan, S Gupta, R Kumar, NR Sinha… - The Ocular Surface, 2024 - Elsevier
Pigment epithelium-derived factor, a glycoprotein, is a potent inhibitor of angiogenesis in
the eye and has been shown to block retinal … DCN overexpression inhibits TGFβ mediated …

Electron Microscopy of the Choroidal Neovascularization

TC Nag, S Gupta - Choroidal Neovascularization, 2020 - Springer
… therapeutic interventions to suppress/modulate … pigment epithelial-derived factor in CNV is
not clear; it is known that its loss could be a problem for ischemia-induced neovascularization […

[HTML][HTML] Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions

N Bhattarai, M Hytti, M Reinisalo, K Kaarniranta… - Immunologic …, 2022 - Springer
factor for AMD. Effects were monitored by measuring the levels of VEGF and anti-angiogenic
pigment epithelium-derived factor (… to choroidal neovascularization in the retina [23, 26], we …