… fungal antibiotic plectasin is a eukaryotic host defence peptide that blocks bacterial cell wall
… to show oligomerization for different lipid II binders including the αβ-defensin copsin 31 and …

… membrane bacterial targets such as Lipid II, outer membrane … Py4 and Lipid II based on that
of plectasin and Lipid II (Figure 1C,… of plectasin with Lipid II [24] also exists in the Py4-Lipid II …

… CSαβ defensins specifically target lipid II.16 These CSαβ … of the lipid II GlcNAc sugar on the
binding affinity of plectasin16 … in certain regions of the cell membrane.5b, 6b We can envision …

… to demonstrate that the cell wall precursor plays a decisive … a lipid II-binding motif with many
others defensins from fungi … lipid II has reduced affinity for plectasin and related defensins…

… that target Lipid II such as the lantibiotic nisin and defensins. We … and dislocating Lipid II
leads to dysfunction of the cell wall … In this study, interactions between plectasin and the solvent-…

… to the bacterial cell wall precursor lipid II and inhibiting the cell wall … Plectasin, the first fungal
CSαβ DLP, showed strong … cellular targets, the DNA-binding properties of P2 or plectasin …

… The bacterial cell wall precursor lipid II is another target of … (B) NaD1 kills fungi by a three-step
mechanism involving cell wall … Once such example is a defensin variant Plectasin, also …

… Lipid II is the site of action of many drugs targeting the cell … Plectasin and its derivative
NZ2114 are non-lytic membrane AMP, which could bind to lipid II to block bacterial cell wall …

… to lipid II, suggesting this cell wall precursor as the target of … determined that plectasin binds
to lipid I and lipid II with a 1 [thin … defensins, lucifensin and gallicin, also bind to lipid II. Shortly …

… dysgalactiae cell membrane was first identified in this study. The PI-stained percentages of
S… important targets of P2. Plectasin with a similar sequence to P2 interacts with lipid II at the …