Effect of CYP3A4, CYP3A5, MDR1 and POR Genetic Polymorphisms in Immunosuppressive Treatment in Chilean Kidney Transplanted Patients

S Contreras-Castillo, A Plaza, J Stojanova… - Frontiers in …, 2021 - frontiersin.org
… Our aim was to test associations between genetic polymorphisms involved in the absorption
and metabolism of CsA and TAC, and drug disposition variables in two groups of Chilean …

[HTML][HTML] ABCB1 gene variants as risk factors and modulators of age of onset of demyelinating disease in Mexican patients

JLG Camacho, TC Vázquez, JJF Rivera… - Neurología (English …, 2023 - Elsevier
… , G2677T/A, and C3435T variants of the ABCB1 gene alter the … C1236T, G2677T/A, and
C3435T variants of ABCB1 and its … with restriction fragment length polymorphism analysis (PCR-…

Prevalence of ABCB1 3435C> T polymorphism in the Cuban population

I Rodeiro Guerra, J Herrea, E Cuétara… - Drug Metabolism and …, 2022 - degruyter.com
… data obtained from Spanish Caucasians, particularly from the northern region of Spain and
to the … Influence of genotype and haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the …

Role of MDR1 Gene Polymorphisms in Human Male Infertility: A Meta-Analysis

A Sohail, A Arshad, T Tariq, A Bibi… - American Journal of …, 2023 - journals.sagepub.com
… The present meta-analysis is performed to determine the association of C1236T and
C3435T polymorphisms in the MDR1 gene. Google Scholar, PubMed, and Science Direct were …

Association between the MDR1 rs1045642 polymorphism and breast cancer risk: An updated meta‑analysis

L Gong, G Hu, L Xu, Y Chen… - Oncology …, 2024 - spandidos-publications.com
… the C3435T mutation in exon 26 of the MDR1 gene is a silent mutation, this polymorphism
… When this gene mutation is overexpressed in breast cancer, it can cause cancer cells to …

ABCB1 C3435T, G2677T/A and C1236T variants have no effect in eslicarbazepine pharmacokinetics

M Peso-Casado, D Ochoa… - Biomedicine & … - repositorioinstitucional.ceu.es
… three ABCB1 common polymorphisms (ie, C3435T, or rs1045642… The protocol complied with
current Spanish legislation on … human MDR1 drug efflux transporter and genetic variation of …

[HTML][HTML] Impact of polymorphisms in transporter and metabolizing enzyme genes on olanzapine pharmacokinetics and safety in healthy volunteers

P Zubiaur, P Soria-Chacartegui, D Koller… - Biomedicine & …, 2021 - Elsevier
… Thus, the objective of this candidate-gene study was to investigate the effect of 72
polymorphisms in 21 genes on olanzapine pharmacokinetics and safety, including transporters (eg …

Effect of the most relevant CYP3A4 and CYP3A5 polymorphisms on the pharmacokinetic parameters of 10 CYP3A substrates

M Saiz-Rodríguez, S Almenara, M Navares-Gómez… - Biomedicines, 2020 - mdpi.com
… most commonly studied reduced-function single nucleotide polymorphism (SNP) is *20, …
highly polymorphic enzyme as CYP3A4*20 allele was present in 1.2% of the Spanish population …

[HTML][HTML] ABCB1 C3435T, G2677T/A and C1236T variants have no effect in eslicarbazepine pharmacokinetics

P Zubiaur, M del Peso-Casado, D Ochoa… - Biomedicine & …, 2021 - Elsevier
… ABCB1 common polymorphisms (ie, C3435T, or … Spanish legislation on clinical research
in humans and was approved by the Research Ethics Committee, authorized by the Spanish

Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy

A Jara-Prado, JL Guerrero-Camacho… - Neurological …, 2024 - Springer
… The three genetic variants C1236T, G2677T/A, and C3435T … the C1236T and C3435T
variants generate conformational … , G2677T/A, and C3435T variants plays a crucial role in P-gp …