… -gp to human variability is the impact of polymorphic genotypes on kinetics, although few
studies … The MDR1 gene is highly polymorphic and several SNPs have been identified, among …

… three ABCB1 common polymorphisms (ie, C3435T, or rs1045642… The protocol complied with
current Spanish legislation on … human MDR1 drug efflux transporter and genetic variation of …

… In our previous studies the C1236T (rs1128503) polymorphism had an influence on ARI
pharmacokinetics. In the current study, the C3435T (rs1045642) and rs4148737 polymorphisms …

… disequilibrium among the genetic polymorphisms of C1236T, G2677T, and C3435T [Citation…
Multi-drug resistance protein 1 (MDR1) belongs to the P-gp family containing polymorphic …

… MDR1 Two studies reported the frequency of polymorphism of CYP2D6 in Saudi patients
[17… Alsaif and his colleagues [25] showed that at 1236 codon of the MDR1 gene, the incidence …

… C3435T genotype in the Caucasians. A similar analysis in Spain also yielded negative results
[24]. … Jamil, and SS Nirni, “Association of MDR1 gene (C3435T) polymorphism and gene …

… Practice and complied with Spanish legislation on clinical research in … all polymorphisms or
the three important ones (C3435T, … This suggests that ABCB1 polymorphism may not have a …

… most commonly studied reduced-function single nucleotide polymorphism (SNP) is *20, …
highly polymorphic enzyme as CYP3A4*20 allele was present in 1.2% of the Spanish population …

… toxicities in the groups with the MDR1 C3435T polymorphism in breast cancer. … role of
genetic polymorphisms and other non-genetic factors as potential modifying risk factors for ADRs. …

… polymorphisms in genes related to drug transporters can regulate cellular accumulation of
platinum drugs. Similarly, variations in genes … the role of genetic polymorphisms in DNA repair…