Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges

Z Mirza, S Karim - Seminars in cancer biology, 2021 - Elsevier
… and suffer concerns of low bioavailability, low cellular uptake, … antibodies allows both in vitro
and ex vivo optical diagnosis, … by activating caspase-8 and c-FLIP, but due to the changes in …

Identification of MYC as an antinecroptotic protein that stifles RIPK1–RIPK3 complex formation

D Seong, M Jeong, J Seo, JY Lee… - … of Sciences, 2020 - National Acad Sciences
… a very transient or weak interaction between the two proteins (… , cIAP-1/2, and c-FLIP proteins
were not affected by changes in … analysis has become a routine tool in biomedical research, …

Morphometrical, morphological, and immunocytochemical characterization of a tool for cytotoxicity research: 3D cultures of breast cell lines grown in ultra-low …

F Malhão, AC Macedo, AA Ramos, E Rocha - Toxics, 2022 - mdpi.com
… After the primary antibody incubation and after each step of the detection system, slides …
We selected a panel of antibodies targeting different outputs for the MCAs’ ICC characterization. …

Regulatory role of sphingosine-1-phosphate and C16: 0 ceramide, in immunogenic cell death of colon cancer cells induced by Bak/Bax-activation

JA Hengst, AJ Nduwumwami, JK Yun - Cancers, 2022 - mdpi.com
… However, recent studies have challenged this assertion by … , low dose ABT/AZD had minimal
effect on levels c-FLIP and … Furthermore, we did not detect the formation of dimeric CRT …

Reactive oxygen species, the trident of Neptune in the hands of hecate; role in different diseases, signaling pathways, and detection methods

M Shayeghan, AM Ansari, F Forouzesh… - Archives of Biochemistry …, 2022 - Elsevier
… -inhibitory protein, ROS downregulates c-FLIP half-life in favor of … spine probes in biomedical
research has been remained … them separately which brings a poor sensitivity. Playing the …

[HTML][HTML] The genetic and molecular basis for canine models of human leukemia and lymphoma

AC Avery - Frontiers in Oncology, 2020 - frontiersin.org
… The expression of downstream anti-apoptotic genes (BCL2, c-FLIP… at low levels in only one
study: TNFAIP3 (14% of 14 cases) and … A greater challenge will be creating more focused …

Identification of a selective RelA inhibitor based on DSE-FRET screening methods

Y Shiroma, G Fujita, T Yamamoto, R Takahashi… - … of Molecular Sciences, 2020 - mdpi.com
… The other 40 compounds had either high autofluorescence or weak inhibitory effects (Table
S1E). Validation was conducted at a compound concentration of 50 µM to investigate …

Combination Therapies Targeting Apoptosis in Paediatric AML: Understanding the Molecular Mechanisms of AML Treatments Using Phosphoproteomics

AA Ali, LV Cairns, KM Clarke, JK Blayney… - … of Molecular Sciences, 2023 - mdpi.com
… ) continues to present treatment challenges, as no “standard … analysis showed both
upregulation of TRAF6 and c-FLIP, … overexpression is linked to poor prognoses and chemotherapy …

PD-L1 blockade by atezolizumab downregulates signaling pathways associated with tumor growth, metastasis, and hypoxia in human triple negative breast cancer

R Saleh, RZ Taha, V Sasidharan Nair, NM Alajez… - Cancers, 2019 - mdpi.com
… Therefore, TNBC treatment remains a challenge. Targeting … and poor survival [2]. It constitutes
10–20% of all breast cancer … the detection of PD-L1 by the anti-PD-L1-APC antibody used …

Small-molecule natural product physachenolide C potentiates immunotherapy efficacy by targeting BET proteins

P Tewary, AD Brooks, YM Xu, EMK Wijeratne… - Cancer research, 2021 - AACR
… the TNF family or agonist antibodies to their death receptors … Elevated levels of cFLIP
are often associated with poor … a grant from the Arizona Biomedical Research Center (grant …