… been made in identifying potent, targeted, and efficient inhibitors … as strong inhibitors by
combining pharmacophore groups of … code 5L2W) and CDK5 and roscovitine (PDB code 1UNL) …

… The pan-selective purine CDK inhibitor roscovitine, which … modification, we employed
molecular modeling. We applied the … In contrast, the most potent inhibitors of the series (IC50 = 2−…

… the molecular interactions of two drug candidates. AZD4573 is a potent inhibitor of CDK9[13]
inducing fast apoptosis across different hematological cancer model patient-derived …

… Roscovitine from the crystal structure (CDK2-Roscovitine: 2A4L… , CDK5, CDK7, and CDK9)
and docked with Roscovitine (… The affinity of different potent inhibitors for CDK isoforms was …

… of (S)-roscovitine was at least partly due to CDK5 inhibition. (S)-roscovitine neuroprotective
… plasticity by increasing BDNF (brain-derived neurotrophic factor) protein level in the …

… in a potent CK1δ/ε inhibitor with an IC 50 value of 14 nM, that was also able to inhibit CDK5
(… Looking at the poses obtained for the molecule of our series on the A 1 AR, A 2A AR, and A …

… in a potent CK1δ/ε inhibitor with an IC50 value of 14 nM, that was also able to inhibit CDK5
(IC50 … Looking at the poses obtained for the molecule of our series on the A1AR, A2AAR, and …

… inhibition of CDK5 has been achieved using peptides derived from p35, and these molecules
have … (29−31) However, no small molecules have been disclosed to date that spare the …

… a potent inhibition against CDK1, CDK2, and CDK5 with IC 50 s … potent inhibition for CDK2
as shown in SU9516 which … obtained results were presented as percent growth inhibition (GI …

… Molecular docking study All the molecular modelling simulations were performed using
Molecular Operating Environment (MOE, 2010.10) software. All minimizations were carried out …