… , integrin has a well-established role in cancer cell signal transduction pathways where
antagonism of integrin activity is a potentially useful strategy of cancer treatment [Citation33]. …

… claimed lower potential of serious … treatment of corticosteroids, while the other (ie, COX-2)
is induced by the inflammatory stimuli or cytokines that can be inhibited by the administration of …

… potential to greatly increase the effectiveness of chemotherapy. Our extensive understanding
of selective COX-2 inhibitor … the widespread administration of selective COX-2 inhibitors as …

… In this article, we review the preclinical and clinical evidences supporting the role of COX-2 …
potential therapeutic use of COX-2 inhibitors as (1) anticonvulsants for epilepsy management …

… could be a suitable choice as adjuvants in the therapeutic management of … COX-2 inhibitors’
efficacy used alone or as part of combination therapy in melanoma. COX-2 inhibitors tested …

… In addition, such a combination can reduce toxicity and chemoresistance and enhance
radiosensitivity, although COX-2 inhibitors-related cardiotoxicity may potentially affect its use. …

… towards COX-2 inhibition compared to indomethacin. Compounds 3d, 3g and 6a exhibited
significantly increased potency towards COX-2 … Furthermore, the selective COX-2 inhibitor 3g …

… COX-2 enzyme and production of immunosuppressive prostaglandin E2 (PGE2). This fact
confirmed COX-2 inhibition … the potential benefits of NSAIDs in the prevention and treatment of …

… common side-effects associated with the chronic administration of NSAIDs. Therefore, we
were interested in determining the ulcerogenic potential of the most potent compounds, 2d, 2f, …

… trials with COX-2 inhibitors for cancer prevention or treatment. … and selective COX-2 inhibitors
(COXIBs) on targets beyond … Therefore, there is a potential role for NSAIDs via activation to …