Genistein, a potential phytochemical against breast cancer treatment-insight into the molecular mechanisms

M Sohel, P Biswas, M Al Amin, MA Hossain, H Sultana… - Processes, 2022 - mdpi.com
inhibited cell division through the underlying mechanism of downregulating COX, topoisomerase
II enzyme TPA, and EROD protein activity [96]. Followed by angiogenesis, GNT (15–30 …

Genistein: a potent anti-breast cancer agent

…, KS Prasad, A Syed, P Reddy, CA Cull… - Current Issues in …, 2021 - mdpi.com
… -breast cancer drugs and genistein by inhibition of breast arterial calcifications. These
findings could lead to possibility of finding new combinations of chemotherapeutic drugs, along …

Genistein: its role in breast cancer growth and metastasis

V Mukund - Current drug metabolism, 2020 - ingentaconnect.com
… role is played by the Notch-1 pathway where the NF-κB inhibition activity by genistein is
induced in triple-negative breast cancer (TNBC), which is the worst type of breast cancer. …

Therapeutic potentials of genistein: New insights and perspectives

S Rasheed, K Rehman, M Shahid… - Journal of Food …, 2022 - Wiley Online Library
… In breast cancer, genistein can inhibit cell differentiation and proliferation, moreover, the
anti-cancer potential of genistein … -mediated AMPK activation proved as a potential therapeutic

Molecular mechanisms of action of genistein in cancer: Recent advances

HS Tuli, MJ Tuorkey, F Thakral, K Sak… - Frontiers in …, 2019 - frontiersin.org
… have also surfaced as potential therapeutic targets of interest … MB-231 human breast cancer
cells, and decreased expression … By blocking it, whether by specific inhibitors or by genistein, …

Genistein as potential therapeutic candidate for menopausal symptoms and other related diseases

P Thangavel, A Puga-Olguín, JF Rodríguez-Landa… - Molecules, 2019 - mdpi.com
… highlight the known inhibitory effects of genistein regarding the … of genistein in breast cancer
cells are the NF-κB and AKT pathways [102,103]. Furthermore, genistein suppresses cancer

Therapeutic effects of dietary soybean genistein on triple-negative breast cancer via regulation of epigenetic mechanisms

M Sharma, I Arora, M Chen, H Wu, MR Crowley… - Nutrients, 2021 - mdpi.com
mechanisms by which GE elicits its anti-carcinogenic properties involve inhibition of cellular
… differentiation, and cell cycle arrest at the G2-M phase [11,12,13]. Specifically, it is known to …

Cellular and molecular mechanisms of genistein in prevention and treatment of diseases: An overview

F Nazari‐Khanamiri… - Journal of Food …, 2021 - Wiley Online Library
inhibition by genistein. According to the result of this study, genistein was understood as a
better inhibitor of NF-κB1 that plays a key role in the inhibition of breast cancer. The findings …

Genistein mediated molecular pharmacology, cell-specific anti-breast cancer mechanism with synergistic effect and in silico safety measurement

M Sohel, P Biswas, M Al Amin, D Dey, H Sultana… - 2021 - preprints.org
… anti-cancer mechanisms of Genistein in multiple BC cells were analyzed, mechanism of …
is an antibiotic that exhibits no inhibitory effects on Adriamycin resistance breast cancer cell. …

Molecular Pathways of Genistein Activity in Breast Cancer Cells

EK Konstantinou, A Gioxari, M Dimitriou… - International Journal of …, 2024 - mdpi.com
Genistein is an inhibitor of the growth of breast cancer cell lines, MDA-468 (estrogen receptor
negative), and MCF-7 and MCF-7-D-40 (estrogen receptor positive) (IC 50 values ranging …