Immunoengineering can overcome the glycocalyx armour of cancer cells

S Park, MJ Colville, JH Paek, CR Shurer, A Singh… - Nature Materials, 2024 - nature.com
… effector cells to display glycocalyx-editing enzymes, including … strategies that overcome the
glycocalyx armour of cancer cells. … Here we combine tools for the precise manipulation and …

Live‐Cell Glycocalyx Engineering

Y Li, M Wang, S Hong - ChemBioChem, 2023 - Wiley Online Library
… 4.3 Adoptive cancer immunotherapy … , uses the cells of our immune system to eliminate
cancer. Unlike the one-size-fits-all medicine, ACT treatments are popular forms of precision

Setting the stage for universal pharmacological targeting of the glycocalyx

K Almahayni, L Möckl - Current Topics in Membranes, 2023 - Elsevier
… of clinical methods for glycocalyx assessment that provides the precision offered by in vitro
… for cancer treatment. Another key target in the focus of glycocalyx-pruning therapy strategies

[HTML][HTML] Don't sugarcoat it: How glycocalyx composition influences cancer progression

A Buffone Jr, VM Weaver - The Journal of cell biology, 2020 - ncbi.nlm.nih.gov
… potential of manipulating the cancer cell glycocalyx, precise editing of the glycocalyx at the
editing the glycocalyx, and potential strategies to prune the specific glycans of the glycocalyx

[HTML][HTML] Decoding strategies to evade Immunoregulators Galectin-1,-3, and-9 and their ligands as novel Therapeutics in cancer Immunotherapy

LS Lau, NBB Mohammed, CJ Dimitroff - International Journal of …, 2022 - mdpi.com
… of cancer immunology, owing to their prominent roles in fine-tuning T cell survival, differentiation,
and anti-tumor … with other short-lived conventional or precision anti-cancer therapeutics. …

Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing

Z Yang, Y Hou, G Grande, C Wang, Y Shi, J Zak… - BioRxiv, 2022 - biorxiv.org
… idea of pursuing desialylation as a therapeutic strategy for cancer treatment has met with only
mixed … & Bertozzi, CR Precision glycocalyx editing as a strategy for cancer immunotherapy. …

[HTML][HTML] Glycosylation Targeting: A Paradigm Shift in Cancer Immunotherapy

X Ren, S Lin, F Guan, H Kang - International Journal of Biological …, 2024 - ncbi.nlm.nih.gov
… to immunotherapy. This review summarizes how glycosylation affects anti-tumor immune …
the latest research progress on targeted glycosylation in immunotherapy. It is hoped that by …

[HTML][HTML] The emerging role of the mammalian glycocalyx in functional membrane organization and immune system regulation

L Möckl - Frontiers in cell and developmental biology, 2020 - frontiersin.org
… into glycocalyx biology and describes the specific challenges glycocalyx research faces. …
to explore the potential of the glycocalyx in therapy and specifically cancer immunotherapy. …

Glycocalyx‐Mimicking Nanoparticles with Differential Organ Selectivity for Drug Delivery and Therapy

D Kim, CH Whang, J Hong, MC Prayogo… - Advanced …, 2024 - Wiley Online Library
… Vukojicic, CR Bertozzi, Precision glycocalyx editing as a strategy for cancer immunotherapy,
… cells exploits antiviral defence for cancer immunotherapy, Nature, 2016, 534, 396401. …

Surface glycan targeting for cancer nano-immunotherapy

Y Choi, J Kim, J Chae, J Hong, J Park, E Jeong… - Journal of Controlled …, 2022 - Elsevier
… In this review, we discuss recent advances in cancer immunotherapies involving glycans
and glycan-targeting technologies based on nanomaterial-assisted local delivery systems. …