… Mosaic loss of the Y-chromosome (LOY) in peripheral blood … LOY in UK Biobank was strongly
associated with levels of sex … a binary predictor was most strongly associated with elevated …

… Genetic association testing in UK Biobank We used genetic data from the “v3” release of
UK biobank … In addition to the quality control metrics performed centrally by UK Biobank, we …

… The most prevalent mCA is the loss of the Y chromosome (… UK Biobank, we focused on
those with a cancer diagnosis. The exposure of interest (mCA) was assessed for the risks of death …

… PM 2.5 measurements and predictions were 0.84 and 16.09 … 85,542 males from the UK
Biobank study validated the TCL1A … Generally, males had higher incidence and mortality in non-…

… Using a newly developed approach, we estimate that 20% of the UK Biobank male … This
research has been conducted using the UK Biobank Resource under application 9905 and …

… However, mosaic LOY in leukocytes is not associated with … from UK biobank (Loftfield et al.
2018); Mosaic LOY is not … that mosaic LOY in blood could become a predictive biomarker of …

… to robustly detect the mosaic loss of chromosome Y (mLOY) are needed given its reported
role in cancer, several age-related disorders and overall male mortality. Intensity SNP-array …

… Using a mouse model of Y-chromosome deletion to confirm UK Biobank prospective study
… morbidity and mortality in men with a higher proportion of mLOY (UK Biobank resource/…

… the UK population. Thirty-seven of these 39 variants had the same effect direction in UK
Biobank … We therefore analyzed whether the associations between mLRR-Y and mortality were …

… of 196,219 UK Biobank men. We detected 12 (0.006%) men with mosaic chromosome X …
We did not detect evidence for mosaic chromosome X loss in any men. We detected 24 (0.01%) …