… other molecules, including mitochondrial DNA (mtDNA), RNA, … Cisplatin binding to mtDNA
further creates adducts that are … ovarian cancer cell, preferentially cisplatin-resistant cells. Our …

… cells. These findings indicate that newly identified mutations in mitochondrial DNA may lead
to acquired cisplatin … This suggests that the binding of CDDP to mtDNA may cause mtDNA …

… of cellular pharmacokinetics. We found that cisplatin predominantly accumulated in
mitochondria of renal tubular epithelial cells, and the amount of binding with mitochondrial DNA (…

… in mitochondrial DNA (mtDNA), because mitochondria are not … preferentially engulf and
outcompete neighboring cells with … and Chinese hamster ovary cells. TREK-1 overexpression …

… carcinoma and Chinese hamster ovarian cells significantly … heteroplasmy SNPs across the
entire mitochondrial genome. … showed that J cybrids preferentially use glycolysis and have …

… complementing defective repair in Chinese hamster cells) XRCC5, … mitochondrial protein
with vital and lethal functions. Cisplatin binds to mitochondrial DNA as well leading to cell …

… up by the mitochondria and interact with mitochondrial DNA or … cells, lipophilic cationic metal
complexes often preferentially … , cisplatin sensitive A549 and cisplatin-resistant A549R cells. …

… with mitochondrial DNA replication catalyzed by the DNA polymerase γ. The ratio between
… in Chinese hamster ovary (CHO) cells demonstrated that the rate of cisplatin-DNA adduct …

… stress, the mitochondria via mitochondrial DNA damage leading to … Cisplatin, carboplatin
and oxaliplatin are all considered to … Furthermore, in Chinese hamster ovary cells, there is not …

… Cisplatin has been shown to induce mitochondrial DNA damage and cause … The
preferential formation of mtDNA adducts attributes to a higher degree of initial binding and lack of …