Prevention of post-thrombotic syndrome with rosuvastatin: A multicenter randomized controlled pilot trial (SAVER)

A Delluc, W Ghanima, MJ Kovacs, S Shivakumar… - Thrombosis …, 2022 - Elsevier
Background Post-thrombotic syndrome (PTS) is one of the most frequent complications of
venous thromboembolism (VTE) leading to considerable morbidity and cost. Apart from
appropriate anticoagulation, there is no drug or medical intervention that helps to prevent
PTS. We conducted a multicenter randomized controlled trial to determine whether
rosuvastatin can prevent PTS. Methods 312 patients receiving standard anticoagulation for a
newly diagnosed VTE were randomly allocated to adjuvant rosuvastatin 20 mg once daily …
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