Long-Term Follow-Up into Adulthood of Pediatric-Onset Primary Sclerosing Cholangitis and Autoimmune Sclerosing Cholangitis

J Hercun, P Willems, M Bilodeau, C Vincent… - JPGN …, 2022 - journals.lww.com
… Baseline laboratory, histological, and imaging characteristics … fibrosis ( 13 ) and histology
was reviewed with a pathologist if … , our study benefits from extensive and long-term follow-up

Diagnosis of primary sclerosing cholangitis beyond childhood is associated with worse outcomes

S Tica, S Alghamdi, C Tait, B Nemera… - Journal of Clinical and …, 2022 - Elsevier
follow-up duration compared to pediatric subjects (P = 0.06). … clinical, laboratory, and histologic
biomarkers of liver disease … In conclusion, our study shows that the outcomes of pediatric

Long‐term outcomes of pediatric‐onset primary sclerosing cholangitis: A single‐center experience in Japan

S Umetsu, K Notohara, T Nakazawa… - … Research, 2019 - Wiley Online Library
… The histological staging of PSC and the histological grading of chronic hepatitis were … clinical
events observed in the pediatric-onset PSC patients during follow up. A total of 16 patients (…

Dominant stricture in paediatric‐onset primary sclerosing cholangitis is associated with impaired prognosis in a long‐term followup

A Tenca, KL Kolho, D Consonni… - United European …, 2024 - Wiley Online Library
… This study was aimed at investigating the impact of DS on the … by colonoscopy and histological
investigations in all patients.… outcomes in pediatric primary sclerosing cholangitis. Hepatol …

Imaging features of primary sclerosing cholangitis: from diagnosis to liver transplant follow-up

P Khoshpouri, RR Habibabadi, B Hazhirkarzar… - Radiographics, 2019 - pubs.rsna.org
childhood microbial exposure are thought to play an important role in disease pathogenesis.
Studies … specimen required for histologic evaluation with a SpyGlass-targeted biopsy (31). …

Impact of paediatric onset primary sclerosing cholangitis on clinical course and outcome of inflammatory bowel disease: a case-control population-based study in …

A Tenca, T Jaakkola, M Färkkilä, J Arola… - Scandinavian Journal …, 2019 - Taylor & Francis
… IBD-PSC children had mild histological inflammation, (3) colon dysplasia was detected in …
last follow-up. To our knowledge, this is the first population-based study comparing histologic

Biliary features in liver histology of children with autoimmune liver disease

A Di Giorgio, A D'Adda, A Marseglia, A Sonzogni… - Hepatology …, 2019 - Springer
… present with a liver biopsy compatible with primary sclerosing cholangitis (PSC), but with a
… fibrosis may be achieved by prospective studies which include follow-up biopsies [22, 23]. …

[HTML][HTML] Natural history of primary sclerosing cholangitis in childhood

AJ Skarby, T Casswall, A Bergquist, L Lindström - JHEP Reports, 2024 - Elsevier
Histology and biochemistry were collected at diagnosis and … pediatric studies of PSC have
reported a poorer outcome than shown in the present study, despite a shorter time of follow-up

Defining primary sclerosing cholangitis: results from an international primary sclerosing cholangitis study group consensus process

CY Ponsioen, DN Assis, KM Boberg, CL Bowlus… - …, 2021 - gastrojournal.org
Histologic features of fibrosing cholangiopathy are present in <20% of liver biopsy … is
substituted for ALP, the consensus definitions in this document are applicable to children. …

[HTML][HTML] Primary sclerosing cholangitis

A Rabiee, MG Silveira - Translational gastroenterology and …, 2021 - ncbi.nlm.nih.gov
studies include a phase 3 study of simtuzumab, a monoclonal antibody against LOXL2 with
anti-fibrotic properties, which did not provide any clinical or histological … 10-year follow-up (67…