… an interconnection of three disulfide bridges present in each protomer that stabilize the fold
of the … The pro-peptide region of proNGF has been reported to assist the correct folding of the …

… were used to express the coding sequence of human NGF precursor as the introns in pro-sequence
promotes disulfide bond formation and correct protein folding [28]. On the contrary, …

… ie, Nerve Growth Factor (NGF), Brain-Derived Neurotrophic … -formed structural element
involved in the chaperonin function of the pro-domains that are known to assist proper folding of …

… folding [[35]], as well as intra- and interchain disulfide bond … In peptide hormones, the
pro-sequence can also play an … -peptide assists in correct folding and disulfide bond formation …

… Nerve guidance conduits (NGC) provide a suitable microenvironment to … regeneration of
injured nerves, which could be the substitutes for autografts. In this study, nerve growth factor (…

… of preproproteins (Eder and Fersht 1995), as for the prodomain of the nerve growth factor (…
Disulfide bonds formed by ten conserved cystine residues constrain the fold, and aligning the …

… , via their axons forming the optic nerve (ON). ON damage leads to axonal degeneration
and death of RGCs, and results in vision impairment. Nerve growth factor (NGF) signalling is …

… by disulfide bonds; iii) protofilaments are formed through the … a suitable biomaterial for
peripheral nerve regeneration.134 … the Gly-Pro-Arg-Pro sequence (GPRP), peptide sequence …

… Propeptides assist their folding and disulfide formation and regulate their activities.… Pro-sequence
assisted folding and disulfide bond formation of human nerve growth factor. J …

… disulfide bond formation and protein folding [8,46]. Analysis of the protein sequence confirmed
the existence of disulfide bonds in … could be utilized to assist the expression of variety of …