Progression of valvular calcification and risk of incident stroke: the Multi-Ethnic Study of Atherosclerosis (MESA)
Background and aims Prevalent valvular calcification (VC) is associated with stroke but little
is known about associations of VC progression with stroke. Methods Progression (interval
increase> 0 Agatston units/year) of aortic valvular calcification (AVC) and mitral annular
calcification (MAC) was assessed by two cardiac CTs over a median of 2.4 years. We
determined the risk of adjudicated total and ischemic stroke using Cox regression adjusted
for cardiovascular disease (CVD) risk factors. Results We studied 5,539 MESA participants …
is known about associations of VC progression with stroke. Methods Progression (interval
increase> 0 Agatston units/year) of aortic valvular calcification (AVC) and mitral annular
calcification (MAC) was assessed by two cardiac CTs over a median of 2.4 years. We
determined the risk of adjudicated total and ischemic stroke using Cox regression adjusted
for cardiovascular disease (CVD) risk factors. Results We studied 5,539 MESA participants …
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