… experience with EGFR inhibitors in lung cancer, drug resistance, … in the first-line treatment
of EGFR-mutant lung cancer (11, 12). … Early work with a gefitinib-sensitive lung cancer cell line …

… Given these properties, 1G and 2G EGFR-TKIs for several … cases treated with this drug as
second line become resistant within … investigations in NSCLC cell lines and animal models that …

… features and suggest that dual EGFR + FGFR inhibition may be … to re-sensitize mesenchymal
cell lines to EGFR inhibition, we … EGFR-mutant NSCLC cells to EGFR inhibitors, we treated …

… lung cancer treatment results in enormous number of saved lives. Clinical development of
EGFR inhibitors … ; and mesenchymal cell lines were more resistant to the compounds inhibiting …

… against cytotoxic reactive oxygen species (ROS) produced by … of lung cancers acquiring
resistance to EGFR inhibitors. … -R EGFR mutant NSCLC cell lines and their TKI-S controls to …

… of cell numbers throughout the process to generate EGFR-mutant lung adenocarcinoma cell
lines with acquired resistance … by EGFR TKI treatment and in cells with acquired resistance. …

… , we generated cell lines resistant to vemurafenib treatment. … Foretinib (F, MET inhibitor)
and lapatinib (L, EGFR inhibitor) … features may be a result of cells’ origin—the A375 cell line is …

… -resistant cell lines from EGFR-mutant NSCLC cell lines and … cells to combined treatment
with MET and EGFR inhibitors (44… Several resistant cell lines displayed EMT features, which we …

… Drug-resistant cellular clones may continue to share some drug-tolerant molecular features,
… Interestingly, 22.2% of NSCLC patients in this study received a prior EGFR inhibitor; however…

… In addition, we present data supporting treatment strategies … isogenic lung cancer cell lines
with AGK/BRAF fusion that we … resistance to EGFR inhibitors in EGFR-mutant lung cancer …