Oxidative stress pathways in pancreatic β-cells and insulin-sensitive cells and tissues: importance to cell metabolism, function, and dysfunction

P Newsholme, KN Keane… - American Journal of …, 2019 - journals.physiology.org
… At the β-cell level, low CAT level results in the inability to protect the pancreatic β-cells
from toxic quantities of H 2 O 2 ; however, this is more likely to be observed when β-cells are …

[HTML][HTML] Comparison of antidiabetic effects of saponins and polysaccharides from Momordica charantia L. in STZ-induced type 2 diabetic mice

Q Wang, X Wu, F Shi, Y Liu - Biomedicine & Pharmacotherapy, 2019 - Elsevier
… intraperitoneal injected with 70 mg/kg day streptozotocin (STZ, dissolved in an ice-cold citrate
… And it was reported that protection of pancreatic β cells by polysaccharides may attribute to …

Ursolic acid regulates gut microbiota and corrects the imbalance of Th17/Treg cells in T1DM rats

W Chen, Y Yu, Y Liu, CJ Song, HH Chen, C Tang… - PLoS …, 2022 - journals.plos.org
… progressive destruction of pancreatic β-cells, and modulate … Other evidence from
animal experiments implies that propolis … , as it protects islet cells from streptozotocin (STZ)-induced …

Assessment of antihyperglycemic effect and acute toxicity of the aqueous Scorzonera undulata extract in rats

M Ajebli, A Amssayef, M Eddouks - Endocrine, Metabolic & …, 2021 - ingentaconnect.com
… be due to the protection of surviving pancreatic β cells and … with the aqueous extract of
propolis. Green arrow indicates … first time in this study realized in STZ-induced rats. Despite the …

Combinatory effect and modes of action of chrysin and bone marrow-derived mesenchymal stem cells on streptozotocin/nicotinamide-induced diabetic rats

HM Sayed, AS Awaad, FEZS Abdel Rahman… - Pharmaceuticals, 2022 - mdpi.com
… are various plant extracts, propolis, blue passionflower (Passiflora … STZ rat model was
applied as a T2DM model based on NA’s protective effects against STZ’s toxic effects on β-cells

[HTML][HTML] Maslinic Acid Protects against Streptozotocin-Induced Diabetic Retinopathy by Activating Nrf2 and Suppressing NF-κB

NA Alsabaani, OM Osman, MA Dallak… - Journal of …, 2022 - hindawi.com
STZ is the best known chemical drug that causes T1DM by causing oxidative damage of the
pancreatic β-cells [… -induced diabetic rats: combined protective effects of Malaysian propolis

[PDF][PDF] Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model

N Azahari, NA Mohd-Shukri… - Adv Obes Weight Manag …, 2020 - researchgate.net
… 2, they cause toxicity to beta cell of pancreas.29A study from … situation, STZ selectively
damages the pancreatic β-cells by … targeted the β-cells being damaged by the induction of STZ for …

Role of polyphenols in combating Type 2 Diabetes and insulin resistance

M Shahwan, F Alhumaydhi, GM Ashraf… - International journal of …, 2022 - Elsevier
The pancreatic β-cells continue to produce surplus insulin, … (multiple low doses)-STZ (streptozotocin)
treated mice for a … patients, administration of Brazilian Green propolis, abundant in …

Honey proteins regulate oxidative stress, inflammation and ameliorates hyperglycemia in streptozotocin induced diabetic rats

F Naqvi, N Dastagir, A Jabeen - BMC complementary medicine and …, 2023 - Springer
… was observed in streptozotocin (STZ) induced diabetic male … Products obtained from honey
bee including propolis, royal jelly, … Destruction in pancreatic β-cells caused by streptozotocin

Involvement of TGF-β and autophagy pathways in pathogenesis of diabetes: a comprehensive review on biological and pharmacological insights

F Heydarpour, S Sajadimajd, E Mirzarazi… - Frontiers in …, 2020 - frontiersin.org
… Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and …
the effect of propolis in enhancing the healing of cutaneous wounds in STZ-induced diabetic …