… mouse Trp53 and Pten alone does not result in rapid development of prostate tumors; however,
combined inactivation leads … as time to prostate-specific antigen relapse, metastasis, or …

… PTEN is a tumor suppressor gene and one of the most … PTEN deletion has been highly
linked to inflammation, in … role of PTEN in PCa, a PTEN prostate-specific deletion mouse model …

… , is strongly linked to advanced prostate cancer progression and … Loss of the tumor suppressor
PTEN is commonly observed in … shown in mice that Pten homozygous deletion and an …

… genetic modification specifically in the prostate gland, we used mice expressing the recombinase
Cre driven by the prostate-specific … of PTEN leads to the inhibition of AR-induced gene …

… prostate cancer upon loss of PTEN expression. Hence, combined prostate-specific Pten and
Smad4 knockout led … with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 8: …

… The prostate-specific Pten-KO mouse model resembles many … (AR) and P53 tumor
suppressor in the early lesions and … showed that Pten-KO in the mouse prostate epithelium led to …

… on multiple genes of interest in prostate-specific or cell-type-… Pten deletion occurs during
prostate postnatal development … The tumor suppressor gene Rb plays a pivotal role in cell-…

… as a novel tumor suppressor gene and prognostic biomarker … malignancy and the second
leading cause of cancer-related death … , we established a murine orthotopic Frmd6/Pten double-…

… Thus, the prostate cancer suppressors PTEN and NKX3.1 … NKX3.1 is a prostate-specific
homeobox gene that controls … loss of Pten expression induced by Cre recombinase in mice …

… by the tumor suppressor gene PTEN. Mutations in this … , leading to the deletion of the floxed
Pten gene in the prostate … this present mouse model, the prostate-specific Cre-LoxP gene …