The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
… a | Image showing perinodal extracellular matrix (ECM) in the mouse facial nerve tract as
revealed by staining for hyaluronan and proteoglycan link protein 2 (HAPLN2). Paranodes are …

Neurons, glia, extracellular matrix and neurovascular unit: a systems biology approach to the complexity of synaptic plasticity in health and disease

C De Luca, AM Colangelo, A Virtuoso… - International journal of …, 2020 - mdpi.com
… The punctual description of different types of neuronal cells with their various morpho-functional
phenotypes goes beyond the aim of this review, thus only common features will be …

[HTML][HTML] Extracellular matrixes and neuroinflammation

DG Jang, HJ Sim, EK Song, T Kwon, TJ Park - BMB reports, 2020 - ncbi.nlm.nih.gov
extracellular matrices in central nervous systems. Interstitial ECM is loosely distributed in
the CNS and neuronal … sulfated CS possesses protective functions from the neuro-inflammation …

A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Extracellular matrix‐based conductive interpenetrating network hydrogels with enhanced neurovascular regeneration properties for diabetic wounds repair

L Fan, C Xiao, P Guan, Y Zou, H Wen… - Advanced …, 2022 - Wiley Online Library
… neuropathy can lead to loss of protective sensation and motor nerve function caused by a …
nerve damage, which further limits diabetic wound repair. [ 37, 38 ] Promoting peripheral nerve

Engineering microenvironment for endogenous neural regeneration after spinal cord injury by reassembling extracellular matrix

H Liu, X Xu, Y Tu, K Chen, L Song, J Zhai… - … applied materials & …, 2020 - ACS Publications
… of cellular elements and regeneration of axons are severely hindered due to the lack of
extracellular matrix (ECM) in the cavity, which thus becomes a major obstacle for neural

An extracellular perspective on CNS maturation: perineuronal nets and the control of plasticity

D Carulli, J Verhaagen - International Journal of Molecular Sciences, 2021 - mdpi.com
… condensed form of an extracellular matrix, which surrounds the … of several neurons in the
adult central nervous system (CNS). … may also represent a protective mechanism against toxic …

The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis

S Ghorbani, VW Yong - Brain, 2021 - academic.oup.com
… In this review, we discuss the extracellular matrix and where … , and in interstitial matrix
between neural cells. We then … inhibits TLR2 signalling and plays a protective role. It has been …

The extracellular matrix of the blood–brain barrier: structural and functional roles in health, aging, and Alzheimer's disease

MJ Reed, M Damodarasamy, WA Banks - Tissue Barriers, 2019 - Taylor & Francis
… , to optimize the neuronal microenvironment and subsequent function. This review will
focus on the origins, components and functional roles of the extracellular matrix (ECM) of the …

Aligned brain extracellular matrix promotes differentiation and myelination of human-induced pluripotent stem cell-derived oligodendrocytes

AN Cho, Y Jin, S Kim, S Kumar, H Shin… - … applied materials & …, 2019 - ACS Publications
… Oligodendrocytes (OLs) play a key role in myelination, which is critical for the development
and functioning of the central nervous system (CNS). OLs produce the protective and …