[HTML][HTML] The immune regulatory role of protein kinase CK2 and its implications for treatment of cancer

H Hong, EN Benveniste - Biomedicines, 2021 - mdpi.com
… There is increasing interest in using CK2 inhibitors for the treatment of various cancers. In …
CK2 regulates the function of immune cells that are important for mounting immune responses

[HTML][HTML] The role of protein kinase CK2 in development and disease progression: a critical review

D Halloran, V Pandit, A Nohe - Journal of Developmental Biology, 2022 - mdpi.com
… , and spermatogenesis is essential for the viability of almost all … adulthood, CK2 continues
to function as a key regulator of … , neuron differentiation, and the immune response. Due to its …

Protein kinase 2 (CK2): A potential regulator of immune cell development and function in cancer

K Husain, TT Williamson, N Nelson… - Immunological …, 2021 - Taylor & Francis
immune cells. However, very few research studies have focused on extrinsic role of CK2 in
regulating immune responses … Prior studies have even demonstrated that protein kinase CK2

[HTML][HTML] Protein kinase CK2: a potential therapeutic target for diverse human diseases

C Borgo, C D'Amore, S Sarno, M Salvi… - Signal transduction and …, 2021 - nature.com
CK2 (previously called casein kinase 2 or CK-II) is one of the first identified protein kinases.
It phosphorylates hundreds of physiological substrates, 2 and is one of the major contributors …

[HTML][HTML] CK2 regulation: perspectives in 2021

SE Roffey, DW Litchfield - Biomedicines, 2021 - mdpi.com
protein kinase CK2 (CK2) family encompasses a small number of acidophilic serine/threonine
kinases … attention are from the protein kinase CK2 family (CK2; formerly known as casein …

Protein kinase CK2: An emerging regulator of cellular metabolism

H Deng, X Rao, S Zhang, L Chen, Y Zong, R Zhou… - …, 2024 - Wiley Online Library
… In summary, protein kinase CK2 phosphorylates glycogen synthase and glucose-6-phosphate
isomerase, regulating glycogen synthesis, glycolysis, gluconeogenesis, and other …

[HTML][HTML] Targeting protein kinases in blood cancer: focusing on CK1α and CK2

Z Spinello, A Fregnani, L Quotti Tubi, L Trentin… - International journal of …, 2021 - mdpi.com
CK2 In humans, protein kinase CK2 exists as a tetrameric enzyme, consisting of two … The
NF-κB transcription factors family is a coordinator of inflammatory response, cell differentiation, …

[HTML][HTML] Protein Kinase CK2 promotes proliferation, abnormal differentiation, and proinflammatory cytokine production of keratinocytes via regulation of STAT3 and Akt …

W Huang, X Zheng, Q Huang, D Weng, S Yao… - The American Journal of …, 2023 - Elsevier
… level in the skin lesions is required in the development of psoriasis by promoting epidermal
hyperplasia, abnormal differentiation, and inflammatory response via regulation of the STAT3 …

[HTML][HTML] Protein kinase CK2—a putative target for the therapy of diabetes mellitus?

E Ampofo, L Nalbach, MD Menger… - International journal of …, 2019 - mdpi.com
… Interestingly, it has also been shown that T2DM inflammation can contribute to the
progression of the disease [30,31]. The inflammatory response is triggered by cytokines such as …

A comprehensive review on the dynamics of protein kinase CK2 in cancer development and optimizing therapeutic strategies

MU Ghani, J Shi, D Yi, L Zhong, H Cui - International Journal of Biological …, 2024 - Elsevier
… These findings underscore the importance of CK2 in regulating apoptosis in cancer cells. A
… Role of CK2 in immune modulation CK2 plays a pivotal role in immune responses, impacting …