… genome, proteomics is now playing an increasing role in this search for … proteomic approaches
may be better suited for early stages of biomarker discovery, while targeted approaches …

… current proteomics studies of brain cancer, in which proteomic … applications of proteomics
from the discovery of biomarkers to … in finding better approaches for the treatment of diseases. …

… to identify and quantitate peptides and proteins using two main approaches: database search
and de novo search. Database searching follows the “Exact Pattern-Matching rule,” which …

… Protein arrays and antibody-based proteomic methods are targeted approaches for protein
… These methods are not optimal for biomarker discovery as they use a directed approach, …

… ’s disease (AD). Here we review the advances and limitations in historic and recent AD
proteomic … Searching PubMed’s literature repository with terms “Alzheimer’s or Alzheimer” and “…

… , so proteins tend to be identified by searching data against a spectral reference library. A
number of DIA methods are available for mass-spectrometry-based proteomics. (67) Some of …

… with common contaminants) using SEQUEST search algorithm through Proteome Discoverer
platform (version 2.1, Thermo Scientific). The search parameters included a maximum of …

… biomarkers in human disease. Comprehensive profiling of blood/plasma/serum proteome is
a … serum and apply the method toward biomarker discovery for Alzheimer’s disease (AD), as …

… a comprehensive search for novel diagnostic biomarkers. A set of reliable protein biomarkers
… specific tests for early disease detection in at-risk segments of the population. Ideally, such …

… in order to find biomarkers of disease with both … proteomics analyses of clinical samples
has been explored widely for discovering novel biomarkers of cancer.9, 10 This approach …