Recently, we demonstrated that Pseudomonas aeruginosa Exotoxin T (ExoT) employs two
distinct mechanisms to induce potent apoptotic cytotoxicity in a variety of cancer cell lines.
We further demonstrated that it can significantly reduce tumour growth in an animal model
for melanoma. During these studies, we observed that melanoma cells that were transfected
with ExoT failed to undergo mitosis, regardless of whether they eventually succumbed to
ExoT‐induced apoptosis or survived in ExoT's presence. In this report, we sought to …

Wood, Stephen; Rush University Medical Center, Immunology/Microbiology Roy, Ruchi;
Rush University Medical Center, Immunology/Microbiology Reiser, Jochen; Rush University
Medical Center, Department of Medicine/Division of Hematology/Oncology/Cell Therapy
Kuzel, Timothy; Rush University Medical Center, Department of Medicine/Division of
Hematology/Oncology/Cell Therapy Shafikhani, Sasha; Rush University Medical Center,
Department of Immunology/Microbiology & Department of Medicine/Division of …