… Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography

SC Jacobsen, NR Speth, M Xiong, MM Herth… - Molecular Imaging and …, 2021 - Springer
… was quantified in a t = 15 min brain section by quantitative DESI… raclopride and SCH23390
in rat brain sections. The compounds were well detected by MALDI-MSI, but no specific ligand

Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development

M Nishidate, M Hayashi, H Aikawa, K Tanaka… - Drug metabolism and …, 2019 - Elsevier
… -MSI has been used for evaluating specific drugs, and we examine the current state of
MALDI-MSI for quantitative analysis of low-molecular-weight drugs in accordance with experience …

Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia

E Fridjonsdottir, R Shariatgorji, A Nilsson… - Science …, 2021 - science.org
… In addition, we performed a qualitative comparison of tissue … using microdialysis and positron
emission tomography (PET), … of any other endogenous ligand not having been considered. …

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for in situ analysis of endogenous small molecules in biological samples

H Liu, Y Pan, C Xiong, J Han, X Wang, J Chen… - TrAC Trends in Analytical …, 2022 - Elsevier
… 4A), resulting in even layer of small crystals and generation of molecular images of lipid
distributions by MALDI imaging [92]. The device was later successfully applied DHB to desalted …

[HTML][HTML] Mass spectrometry imaging in drug distribution and drug metabolism studies–Principles, applications and perspectives

JR Granborg, AM Handler, C Janfelt - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
… PET ligands (Positron Emission Tomography), … quantitative aspects where direct quantitation,
semi-quantification or establishment of limits of detection is part of an otherwise qualitative

Sample preparation strategy for the detection of steroid-like compounds using MALDI mass spectrometry imaging: pulmonary distribution of budesonide as a case …

R Zecchi, P Franceschi, L Tigli, D Amidani… - Analytical and …, 2021 - Springer
imaging technologies such as nano positron emission tomography (Nano/PET) and fluorescent
dye imaging [13]. … Furthermore, we succeeded in setting up a quantitative MSI method for …

MALDI sample preparation methods: A mini review

AA Patil, MJN Descanzo, VB Dhisale… - International Journal of …, 2024 - Elsevier
… In particular, these techniques aim to improve signal intensities, reproducibility, and detection
limits, making them suitable for both qualitative and quantitative MALDI mass analysis. …

[HTML][HTML] Monitoring dexamethasone skin biodistribution with ex vivo MALDI-TOF mass spectrometry imaging and confocal Raman microscopy

E Pena-Rodríguez, T García-Berrocoso… - International Journal of …, 2023 - Elsevier
… semiquantitative data together with qualitative images of biodistribution, which is a … Qualitative
and quantitative MALDI imaging of the positron emission tomography ligands raclopride

Spatially resolved absolute quantitation in thin tissue by mass spectrometry

V Kertesz, JF Cahill - Analytical and Bioanalytical Chemistry, 2021 - Springer
… challenges to achieving quantitative MSI with MALDI, which … Many of the quantitative
approaches outlined for MALDI-MSI … examples of quantitative and qualitative elemental imaging

Absolute quantitative imaging of sphingolipids in brain tissue by exhaustive liquid microjunction surface sampling–liquid chromatography–mass spectrometry

Q Wu, Z Huang, Y Wang, Z Zhang, H Lu - Journal of Chromatography A, 2020 - Elsevier
… The absolute quantitative spatial distributions of targeted metabolites largely matched
previously reported results. The method was applied to a study on the quantitative spatial changes …