… Caenorhabditis elegans ortholog of Regnase-1, we have uncovered its functional relationship
with RLE-1, … the ets-4 decay, RLE-1 could regulate additional mRNAs independently from …

… be used as a biomarker of ageing and the ageing pigment lipofuscin is accumulated as a …
in life extension by regulating the entry of the transcription factor DAF-16 and heat shock factor-…

… CHIP targets the insulin receptor and marks it by monoubiquitination for endocytosis and …
elegans, the FOXO transcription factor DAF-16 is a substrate for a ubiquitin ligase called RLE-1 …

… aging are known to play a crucial role in development, health and disease. Biological processes
such as cell death and aging … of programmed cell death, while DAF-16 and BAR-1 are …

… a new interaction of DAF-16 in the cell nucleoli, where we observed DAF-16 migration, …
elegans, the DAF-16 transcription factor is a key aging regulator that governs the Insulin/IGF-1 …

… of longevity by E3 (RLE-1) that ubiquitinates DAF-16 directing it … Importantly for this research,
DAF-16 was described to regulate … elegans seems to stop aging while exposed to the cold, …

… with ageing and determined their expressions, including daf-16 (Fork-… gene of daf-16 and
regulates the expression of daf-16 by a … Sir-2.1 is a cofactor of daf-16 that can bind to daf-16 to …

… transcription factors consisting of DAF-16 in Caenorhabditis elegans, dFOXO in Drosophila
… The loss of RLE-1, an E3 ubiquitin ligase that catalyzes DAF-16 polyubiquitination, extends …

… The decline of proteostasis is a hallmark of aging that is, in part, … aging are largely unknown.
In this study, we examined lysine acetyltransferase regulation of the HSR and HSF-1 in C. …

… cardiac accumulation of polyubiquitinated proteins and abnormal … of the E3 ubiquitin ligase
of DAF-16, to disrupt ubiquitination, … and modulates longevity in Caenorhabditis elegans. Nat …