… Furthermore, thorough research on the pathogenesis of aging to identify interventions that …
treatment methods for aging-related diseases (depletion of senescent cells, stem cell therapy, …

… High levels of ROS can directly damage DNA, proteins, and lipids in cells, causing a DNA
damage … This leads to cell senescence and development of aging-related diseases [26]. DNA …

… In addition, cellular senescence influences neighboring cells via gap-junction contacts,
growth factors, interleukins, and ROS, highlighting the importance of the microenvironment in …

… increased risk of age-related diseases. Cellular senescence can be divided into premature
… in oxidatively damaged cells, 72 whereas high levels of ROS in cells are considered a driving …

… Cell senescence is a phenomenon in which cells … age, and contributes to age-related
diseases [50]. Chronic low-level inflammation exposes cells to constant increased levels of ROS, …

… molecular links between cellular senescence and age-associated complications and
highlight novel … that produce high levels of reactive oxygen species (ROS). There is usually an …

… expression of p53, both associated with the senescent phenotype [46]. … reactive oxygen
species (ROS) at adipose tissue [47]. These increased ROS may in turn induce cell senescence …

… , neurodegenerative diseases, … cellular senescence in diseases of aging and to assess
some of the progress made thus far toward senotherapeutic approaches to extend healthy aging …

… release reactive oxygen species (ROS), which further drive the … made recently in understanding
the molecular mechanisms involved in cellular senescence in chronic lung diseases. It is …

… of aging, one of which relates aging to the damage to cell … that the molecular mechanisms
of aging are also associated with … Uncontrolled ROS production contributes to aging and the …