… antigen receptor that recognizes a disease-relevant antigen (… To this end, the inhibition of
Foxp3 negative regulators … suppressive function in experimental models of autoimmunity and …

… receptor (Rilonacept) (75). Despite widespread use of these IL-1 inhibitors in patients with
autoimmune … Tfh to produce the two main B-cell activation cytokines. Furthermore, IL-1 alone …

… and autoimmune disorder initiated by several antigen… and dysfunction of mitochondrial
respiration, and inhibition of … Rubicon is a negative regulator of autophagy and increases …

… Clinically, β2GPI is the primary antigen in the autoimmune condition antiphospholipid …
inhibition of FXa/thrombin by its natural regulator or alternatively through preventing activation of …

… miR155 is also closely related to the regulation of autoimmune … tory signals through this
pathway as negative regulators [30, … MicroRNA-155 controls T helper cell activation during viral …

… tion of Ca2+-NFAT signaling (Figures 3A and 3C). To further asses the concept that expression
of ZAP70 may act as a competitive inhibitor of SYK-mediated activation of the BLNK-Ca2…

… restriction serves to mitigate the progression of autoimmune … , especially in patients at advanced
Rai-Binet stages. Elevated … function of BTLA is the negative regulation of T cell activation …

… several autoimmune diseases, but its mechanism of action is unknown. Here, we found that
IRGM is a master negative regulator of … Using autophagy and proteasome inhibitors, we next …

… in turn causes inhibition of T cells, thus preventing the autoimmune … of glucocorticoids prior
to RAI treatment. Citation78 Similarly, … that negative regulation of cytokine mediated signalling …

… The second (co-stimulatory) T cell activation signal is mediated … For example, TCR T cells
and chimeric antigen receptor (… expression of inhibitory receptors and negative regulators, as …