Randomized phase II trial evaluating treatment with EGFR-TKI associated with antiestrogen in women with nonsquamous advanced-stage NSCLC: IFCT-1003 LADIE …

J Mazieres, F Barlesi, I Rouquette, O Molinier… - Clinical Cancer …, 2020 - AACR
randomized, phase II study aimed to evaluate erlotinib plus fulvestrant versus erlotinib alone
… OS observed with erlotinib plus fulvestrant when considering all of the patients, a subgroup …

XENERA-1: A randomised double-blind Phase II trial of xentuzumab in combination with everolimus and exemestane versus everolimus and exemestane in patients …

P Schmid, J Cortes, A Joaquim, NM Jañez… - Breast Cancer …, 2023 - Springer
randomised Phase II study assessed xentuzumab plus everolimus and exemestane in
patients … plus fulvestrant versus fulvestrant; median PFS 1.9–2.7 months) [25, 26]. In both …

A phase II open label study of everolimus in combination with endocrine therapy in resistant hormone receptor-positive HER2-negative advanced breast cancer

DA Yardley, W Liggett, M Mainwaring, A Castrellon… - Clinical Breast …, 2020 - Elsevier
… In this phase II study, we used everolimus in addition to the most recent endocrine therapy
during which a patient's … therapies in this study: exemestane (11 patients; 23%), fulvestrant (10 …

[HTML][HTML] Investigation of combination treatment with an aromatase inhibitor exemestane and carboplatin-based therapy for postmenopausal women with advanced …

PA Young, DC Márquez-Garbán, ZS Noor… - JTO clinical and …, 2021 - Elsevier
patients with advanced NSCLC with high-dose fulvestrant in combination with erlotinib in a
phase 2 clinical trial … ) and overall survival (OS) in patients with wild-type EGFR tumors but not …

[HTML][HTML] Hormone gene signature guides a novel therapeutic opportunity to improve sensitivity to HER family inhibition in lung cancer

ZA Yochum, LP Stabile - Translational Lung Cancer Research, 2020 - ncbi.nlm.nih.gov
phase II trial compared the combination of fulvestrant and erlotinib versus single-agent erlotinib
in NSCLC patients (… This work suggests that fulvestrant and dacomitinib may be effective …

Cyclin-dependent kinase (CDK) inhibitors in solid tumors: a review of clinical trials

E Panagiotou, G Gomatou, IP Trontzas… - Clinical and …, 2022 - Springer
… of this study, it is reasonable to use either fulvestrant or … In another randomized phase
II study (NCT01684215) of the … erlotinib in third-line therapy of KRAS-mutated metastatic …

[HTML][HTML] Inhibiting pathways predicted from a steroid hormone gene signature yields synergistic antitumor effects in NSCLC

AA Almotlak, M Farooqui, JM Siegfried - Journal of Thoracic Oncology, 2020 - Elsevier
… a phase II randomized clinical trial, the EGFR TKI erlotinibpatients who received the dual
therapy. The improvement when combining erlotinib (which only targets EGFR) with fulvestrant

Phase II study of neratinib in older adults with HER2 amplified or HER2/3 mutated metastatic breast cancer

Y Yuan, JS Lee, SE Yost, T Stiller, MS Blanchard… - Journal of geriatric …, 2021 - Elsevier
patients with ER + HER2 mutant MBC treated with neratinib plus fulvestrant, an overall RR of
18.2% (2… HER-directed TKI, specifically lapatinib and erlotinib, is reduced in the presence of …

[HTML][HTML] Relationship between progression-free survival and overall survival in randomized clinical trials of targeted and biologic agents in oncology

LM Hess, A Brnabic, O Mason, P Lee, S Barker - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
… by which survival is extended for patients with cancer who are treated with … clinical trial
design or biases in the interpretation of data. This study was designed to examine the role of study

A Phase I Dose-Escalation and Dose-Expansion Study of FCN-437c, a Novel CDK4/6 Inhibitor, in Patients with Advanced Solid Tumors

A Patnaik, E Hamilton, Y Xing, DW Rasco, L Smith… - Cancers, 2022 - mdpi.com
… AIs or fulvestrant (as indicated), or other anticancer agents such as PI3K or mTOR inhibitors.
To this end, two ongoing phase II studies in China are evaluating FCN-437c alone versus in …