Single-dose psilocybin treatment for major depressive disorder: A randomized clinical trial

CL Raison, G Sanacora, J Woolley, K Heinzerling… - Jama, 2023 - jamanetwork.com
treatments for major depressive disorder (MDD) 1 -5 and in part by recent studies suggesting
that psilocybin engenders a rapid … lost to follow-up; 3 participants in the psilocybin group …

Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up

N Gukasyan, AK Davis, FS Barrett… - Journal of …, 2022 - journals.sagepub.com
… outcome measure (Quick Inventory of Depressive Symptoms). … depression severity scores
favored the high-dose psilocybin … Although psilocybin treatment of MDD appears promising, …

The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis

SB Goldberg, BT Pace, CR Nicholas, CL Raison… - Psychiatry …, 2020 - Elsevier
anxiety and depression in samples with elevated symptoms. … pre-follow-up effects on anxiety
and depression were large (… Rapid and sustained symptom reduction following psilocybin

Psilocybin for treatment-resistant depression without psychedelic effects: study protocol for a 4-week, double-blind, proof-of-concept randomised controlled trial

MI Husain, DM Blumberger, DJ Castle, N Ledwos… - BJPsych …, 2023 - cambridge.org
… with major depressive disorder and treatment-resistant depression (… model of depression,
ketanserin followed by psilocybin had … ’s antidepressant effects may be mediated through rapid

[HTML][HTML] Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomised clinical trial

R von Rotz, EM Schindowski, J Jungwirth… - …, 2023 - thelancet.com
… 25 mg, 7 days apart) together with psychological support resulted in rapid symptom
improvement in patients with treatment-resistant depression that persisted at a 6 months follow-up. …

[HTML][HTML] Single-dose psilocybin for a treatment-resistant episode of major depression: Impact on patient-reported depression severity, anxiety, function, and quality of …

GM Goodwin, ST Aaronson, O Alvarez, M Atli… - Journal of Affective …, 2023 - Elsevier
… (the day after psilocybin administration) and … Psilocybin was also rapid-acting, with treatment
differences observed as early as Day 2 on the QIDS-SR-16 and PANAS total scores after

Effects of psilocybin-assisted therapy on major depressive disorder: a randomized clinical trial

AK Davis, FS Barrett, DG May, MP Cosimano… - JAMA …, 2021 - jamanetwork.com
rapid, large decrease in mean (SD) depression score among participants from baseline to day
1 after psilocybin … This substantial decrease remained through week 4 after session 2 (6.0 […

… mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression

LJ Mertens, MB Wall, L Roseman… - Journal of …, 2020 - journals.sagepub.com
… FC after psilocybin in 19 patients with TRD who underwent two psilocybin-assisted therapy
… the criteria for severe or very severe depression (self-rated Quick-Inventory of Depressive

Acute and sustained reductions in loss of meaning and suicidal ideation following psilocybin-assisted psychotherapy for psychiatric and existential distress in life …

S Ross, G Agin-Liebes, S Lo, RJ Zeifman… - ACS pharmacology & …, 2021 - ACS Publications
… controlled trial in which psilocybin-assisted psychotherapy (PAP) produced rapid and … that
psilocybin treatment would be associated with significant acute and sustained reductions in SI …

[HTML][HTML] Single-dose psilocybin for a treatment-resistant episode of major depression

GM Goodwin, ST Aaronson, O Alvarez… - … Journal of Medicine, 2022 - Mass Medical Soc
After at least 6 hours and when the psychedelic effects of the drug had fully dissipated,
participants returned home. The trial followed participants for 12 weeks after treatment. …