[图书][B] CYP2D is Functional in the Brain and Alters Haloperidol-Induced Side Effects
C Tolledo - 2020 - search.proquest.com
… Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by
different mechanisms. Progress in Neuro-Psychopharmacology and Biological Psychiatry 78…
different mechanisms. Progress in Neuro-Psychopharmacology and Biological Psychiatry 78…
Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different …
PJ Danek, WA Daniel - Cells, 2021 - mdpi.com
… serotonin) and in the metabolism of neurosteroids. The present … , with minimal side effects
[4,5,6,7,8]. Iloperidone is extensively … Therefore, regional changes in brain CYP2D activity may …
[4,5,6,7,8]. Iloperidone is extensively … Therefore, regional changes in brain CYP2D activity may …
The mechanisms of interactions of psychotropic drugs with liver and brain cytochrome P450 and their significance for drug effect and drug-drug interactions
WA Daniel, E Bromek, PJ Danek, A Haduch - Biochemical Pharmacology, 2022 - Elsevier
… Changes in the activity of brain CYP2D and metabolism of haloperidol affect the acute and
chronic side-effects of this drug measured in the rat behavioral models, and may be a risk …
chronic side-effects of this drug measured in the rat behavioral models, and may be a risk …
Cytochrome P450 enzymes and metabolism of drugs and neurotoxins within the mammalian brain
MR Stocco, RF Tyndale - Advances in Pharmacology, 2022 - Elsevier
… Selective manipulation of CYP2D in the rat brain in vivo alters drug and … acute and chronic
extrapyramidal side effects. Inhibiting CYP2D in the rat brain increased CNS haloperidol …
extrapyramidal side effects. Inhibiting CYP2D in the rat brain increased CNS haloperidol …
CYP2D in the Brain Alters Response to Drugs and Neurotoxins
M Stocco - 2021 - search.proquest.com
… in CYP2D metabolism may contribute to differences in acute … haloperidol, which can cause
extrapyramidal side-effects … In rats, inhibiting CYP2D in the brain reduced the severity of …
extrapyramidal side-effects … In rats, inhibiting CYP2D in the brain reduced the severity of …
Alterations of cytochrome P450s and UDP-glucuronosyltransferases in brain under diseases and their clinical significances
Y Sheng, H Yang, T Wu, L Zhu, L Liu… - Frontiers in …, 2021 - frontiersin.org
… and their metabolites in brain, in turn, altering drug response. Some … Moreover, their side
effects and drug efficacy are not … , CYP2D-mediated metabolites of haloperidol in brain may …
effects and drug efficacy are not … , CYP2D-mediated metabolites of haloperidol in brain may …
Human CYP2D6 is functional in brain in vivo: evidence from humanized CYP2D6 transgenic mice
C Tolledo, MR Stocco, S Miksys, FJ Gonzalez… - Molecular …, 2020 - Springer
… drug metabolism specifically within the brain may alter brain … drugs that may produce acute
extrapyramidal side effects [30]; … In rats, a CYP2D-mediated haloperidol metabolite formed in …
extrapyramidal side effects [30]; … In rats, a CYP2D-mediated haloperidol metabolite formed in …
The role of CYP2D in rat brain in methamphetamine-induced striatal dopamine and serotonin release and behavioral sensitization
MR Stocco, AA El-Sherbeni, B Zhao, M Novalen… - …, 2021 - Springer
… Variable CYP2D metabolism in the brain may alter CNS drug/… of these can be modeled by
behavioral sensitization in rats. … of CYP2D in the brain in MAMP-induced acute behavioral …
behavioral sensitization in rats. … of CYP2D in the brain in MAMP-induced acute behavioral …
Propranolol is a mechanism‐based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6‐transgenic mice: Effects on activity and drug responses
EC Tolledo, S Miksys, FJ Gonzalez… - British Journal of …, 2020 - Wiley Online Library
… Propranolol is an MBI of rat CYP2D (we use CYP2D … metabolism (eg, changes in serum
drug levels) and drug response, including side effects, as we have done here using haloperidol-…
drug levels) and drug response, including side effects, as we have done here using haloperidol-…
Cytochrome P450 expression and regulation in the brain
W Kuban, WA Daniel - Drug Metabolism Reviews, 2021 - Taylor & Francis
… On the other hand, changes in the activity of brain CYP2D and consequent alterations in
metabolism of the antipsychotic drug haloperidol diversely affect acute and chronic side-effects …
metabolism of the antipsychotic drug haloperidol diversely affect acute and chronic side-effects …