Melatonin, its metabolites and their interference with reactive nitrogen compounds

R Hardeland - Molecules, 2021 - mdpi.com
… as products of reactions with peroxynitrite [115]. However, the outcome concerning
melatonin nitration by peroxynitrite remained rather modest. One study reported the absence of …

Melatonin attenuates peroxynitrite-induced meiosis dysfunction in porcine oocytes

Y Cao, R Li, W Li, H Liu, Y Cai - Reproductive Sciences, 2021 - Springer
… work mechanism remains to be further clarified. In this study, it was shown that peroxynitrite
… had the best response according to our result) melatonin exhibited significant improvements …

Interactions of melatonin, reactive oxygen species, and nitric oxide during fruit ripening: an update and prospective view

FJ Corpas, M Rodríguez-Ruiz… - Journal of …, 2022 - academic.oup.com
… molecule related to NO was not analyzed in this study. Melatonin is known to react with
peroxynitrite, and it could be expected that in a cellular environment, this would be a mechanism

Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems

JA Boutin, M Liberelle, S Yous, G Ferry… - … of Pineal Research, 2024 - Wiley Online Library
… found in plants were also studied on the same acellular model… than trolox, in this study,
melatonin itself was surprisingly not … Reaction of peroxynitrite with melatonin: a mechanistic study. …

Computational Quantum Study of Intermediates Formed During the Partial Oxidation of Melatonin

OS Oladiran - 2020 - search.proquest.com
… In this research, ab initio quantum chemistry techniques were … during the partial oxidation
of melatonin by hydroxyl radical. … HAT mechanism pathway of the reaction of 6-OH melatonin

Anti-Warburg effect of melatonin: a proposed mechanism to explain its inhibition of multiple diseases

RJ Reiter, R Sharma, S Rosales-Corral - International journal of …, 2021 - mdpi.com
studied were human leiomyomas, a malignant tumor type with high metabolism. In this
study, orally administered melatonin, … the dissimilar oxidative response to melatonin in two …

Molecular mechanisms of melatonin-mediated cell protection and signaling in health and disease

DM Kopustinskiene, J Bernatoniene - Pharmaceutics, 2021 - mdpi.com
… oxide and peroxynitrite. Melatonin effectively terminates the radical reaction chain without
… Besides this mechanism, melatonin can be transported across the plasma membrane by the …

Mechanism of melatonin metabolism by CYP1A1: what determines the bifurcation pathways of hydroxylation versus deformylation?

T Mokkawes, ZQ Lim, SP de Visser - The Journal of Physical …, 2022 - ACS Publications
… To find out whether these differences in substrate orientation would trigger changes in
catalysis and product distributions, we expanded our work with catalytic reaction mechanism

[HTML][HTML] Melatonin ameliorates the drug induced nephrotoxicity: Molecular insights

Z Raza, Z Naureen - nefrologia, 2020 - Elsevier
… efficiently eradicate the chain reaction of free radical … has been reported to be the potent
scavenger of peroxynitrite free … nephroprotective mechanism of melatonin against cisplatin. …

Interaction between melatonin and no: Action mechanisms, main targets, and putative roles of the emerging molecule nomela

SE Martínez-Lorente, M Pardo-Hernández… - International Journal of …, 2022 - mdpi.com
… in cell metabolism still needs further research [13], some known … physiology and plant stress
response, this review focuses on … can also act through this mechanism, as described in what …