Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against …
B Zhou, H Li, Z Cui, D Li, H Geng, J Gao… - European Journal of …, 2020 - Elsevier
… Interestingly, the above SAR of 8 for AChE is very similar to that of 2-aryl-β-carbolin-2-ium
salts … In fact, 8 can be considered as simple analogues of 2-aryl-β-carbolin-2-niums [24]. …
salts … In fact, 8 can be considered as simple analogues of 2-aryl-β-carbolin-2-niums [24]. …
DYRK1A inhibitors for disease therapy: current status and perspectives
… DYRK1A is involved in multiple biological functions. For … Last but not least, new
strategies are being developed for in … Some investigators conducted SAR studies on …
strategies are being developed for in … Some investigators conducted SAR studies on …
Synthesis and biological validation of a harmine-based, central nervous system (CNS)-avoidant, selective, human β-cell regenerative dual-specificity tyrosine …
K Kumar, P Wang, J Wilson, V Zlatanic… - Journal of medicinal …, 2020 - ACS Publications
… strategy to investigate structure–activity relationships of harmine analogs for both DYRK1A
activity and … In conclusion, through extensive SAR studies and biological characterization, we …
activity and … In conclusion, through extensive SAR studies and biological characterization, we …
Aza-Annulation of 1,2,3,4-Tetrahydro-β-carboline Derived Enaminones and Nitroenamines: Synthesis of Functionalized Indolizino[8,7-b]indoles, Pyrido[1,2-a:3,4-b′]diindoles …
A Avadhani, P Iniyavan, A Acharya, V Gautam… - ACS …, 2019 - ACS Publications
… We next extended our aza-annulation strategy for the synthesis … (16) Fascaplysin displays
a broad range of biological activities, … with potential biological activity employing this protocol. …
a broad range of biological activities, … with potential biological activity employing this protocol. …
Diabetic kinome inhibitors—A new opportunity for β-cells restoration
… , 4-(7-methoxy-1-methyl-β-carbolin-9-yl)butanamide proved to be the … SAR studies on the
aminopyrazine scaffold targeted the … , biological activity with future direction of development are …
aminopyrazine scaffold targeted the … , biological activity with future direction of development are …
Structure-based discovery of ABCG2 inhibitors: a homology protein-based pharmacophore modeling and molecular docking approach
… As the case of tetrahydroxy-β-carbolin derivative, … biological activity test of tetrahydro-β-carbolin
group when ethylated -NH- group on this molecule, the biological activity …
group when ethylated -NH- group on this molecule, the biological activity …
Design, synthesis, and antifungal evaluation of neocryptolepine derivatives against phytopathogenic fungi
JK Zhu, JM Gao, CJ Yang, XF Shang… - Journal of agricultural …, 2020 - ACS Publications
… Given the broad pharmacological activities of neocryptolepine, … for further structural modification
and SAR development. … Meanwhile, this study also offered a strategy to achieve highly …
and SAR development. … Meanwhile, this study also offered a strategy to achieve highly …
DNA related enzymes as molecular targets for antiviral and antitumoral chemotherapy. A natural overview of the current perspectives
HA Garro, CR Pungitore - Current Drug Targets, 2019 - ingentaconnect.com
… activity in a specific manner [8]. Consequently, some proteins can become true molecular
targets and then develop certain pharmacological action. … allow the development of new leads, …
targets and then develop certain pharmacological action. … allow the development of new leads, …
Design, Synthesis and Anticancer Activity of Β-Carboline Based Pseudo-Natural Products by Inhibiting Akt/Mtor Signaling Pathway
L Lv, K Song, Y Xiao, J Zheng, W Zhang, L Li… - Mtor Signaling … - papers.ssrn.com
… sensible and rational design strategy in recent years, providing … The structure-activity
relationship (SAR) against A549 is … molecules for exploring relative biological activity and ability to …
relationship (SAR) against A549 is … molecules for exploring relative biological activity and ability to …
Uncovering the relationship between hepatocellular carcinoma and compounds belonging to Simaroubaceae using a network pharmacology approach and molecular …
M Wen, GZ Sen, H Pei, D Xin - Computational Toxicology, 2021 - Elsevier
… D (PA47-a), β-carbolin-1-yl3-(4, 8-dimethoxy-β-carbolin-1-yl)-1-… Network pharmacology is a
new drug discovery strategy … Another important aspect is highlighted by this SAR study deals …
new drug discovery strategy … Another important aspect is highlighted by this SAR study deals …