Peptide receptor radionuclide therapy

J Hofland, T Brabander, FA Verburg… - The Journal of …, 2022 - academic.oup.com
… The actions of 14-amino acid and 28-amino acid are … protection with concurrent amino acid
infusion is usually given (9)… a combination of 177 Lu-DOTATATE and 90 Y-SSAs can result in …

90Y/177Lu-DOTATOC: From Preclinical Studies to Application in Humans

L Uccelli, A Boschi, C Cittanti, P Martini, S Panareo… - Pharmaceutics, 2021 - mdpi.com
Radionuclide Therapy) is a promising modality treatment for … the goal of receptor-mediated
radiometabolic therapy and the … of [ 90 Y]Y-DOTATOC has decreased by 65% intravenous

Peptide receptor radionuclide therapy

A Yordanova - Clinical Nuclear Medicine, 2020 - Springer
… hour before therapy and over 2 h after therapy. The amino acid infusion is associated with
… The duration of the nephroprotective infusion of amino acids after Yttrium-90-labelled PRRT …

Alpha-peptide receptor radionuclide therapy using actinium-225 labeled somatostatin receptor agonists and antagonists

M Shi, V Jakobsson, L Greifenstein, PL Khong… - Frontiers in …, 2022 - frontiersin.org
… Treatment with 90 Y-DOTATOC stopped rapid tumor … is replaced by the natural amino acid
Thr. This somatostatin analog was … despite the lack of receptor-mediated internalization (127). …

Peptide receptor radionuclide therapy targeting the somatostatin receptor: basic principles, clinical applications and optimization strategies

N Ahmadi Bidakhvidi, K Goffin, J Dekervel, K Baete… - Cancers, 2021 - mdpi.com
… with 90 Y-DOTATOC [43]. Patients received up to four cycles of … associated with a better
survival after treatment with 90 … to the nephroprotective amino acid infusion. Transient grade 3 or …

Peptide receptor radionuclide therapy (PRRT): innovations and improvements

E Merola, CM Grana - Cancers, 2023 - mdpi.com
… by administering a positively charged amino acid infusion (L-… failure of other treatments,
the European Society for Medical … NETs resistant to SSAs and tandem therapy with [ 90 Y]Y-/[ …

NANETS/SNMMI consensus statement on patient selection and appropriate use of 177Lu-DOTATATE peptide receptor radionuclide therapy

TA Hope, L Bodei, JA Chan, G El-Haddad… - Journal of Nuclear …, 2020 - Soc Nuclear Med
… . Receptor-mediated radionuclide therapy with 90 Y-DOTATOC in association with amino
acid infusion: a phase I study. Eur J Nucl Med Mol Imaging. 2003;30:207–216. …

Strategies towards improving clinical outcomes of peptide receptor radionuclide therapy

NS Minczeles, J Hofland, WW de Herder… - Current Oncology …, 2021 - Springer
… 177 Lu-DOTATATE, 90 Y-DOTATOC or a combination of these … by the concurrent infusion
of an amino acid combination, … with concomitant amino acid infusion and exclusion of patients …

Peptide receptor radionuclide therapy in thyroid cancer

S Gubbi, CA Koch, J Klubo-Gwiezdzinska - Frontiers in endocrinology, 2022 - frontiersin.org
… to the renoprotective amino acid infusion that is concurrently … MTC was associated with
response to therapy in 29% of the … ATC, and 90 Y-DOTATOC therapy failed to achieve an …

[HTML][HTML] Peptide receptor radionuclide therapy for patients with advanced lung carcinoids

BG Naraev, RA Ramirez, AT Kendi, TR Halfdanarson - Clinical lung cancer, 2019 - Elsevier
associated with amino acid infusions that patients also received, and which resolved after
completion of the infusions. … renal AE, whereas 90 Y-DOTATOC monotherapy was identified as …