Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid
C Dorn, D Petroff, M Stoelzel, MG Kees… - Journal of …, 2021 - academic.oup.com
… and subcutaneous tissue of obese patients undergoing bariatric surgery, compared with a
… were distinctly lower in the obese group than in the non-obese group, but decreased more …
… were distinctly lower in the obese group than in the non-obese group, but decreased more …
Lack of pharmacokinetic basis of weight-based dosing and intra-operative re-dosing with cefazolin surgical prophylaxis in obese patients: implications for antibiotic …
S Blum, CB Cunha, BA Cunha - Surgical Infections, 2019 - liebertpub.com
… The optimal IV dose for skin and soft tissue infections in patients with normal renal …
cefazolin concentrations, but significantly lower unbound cefazolin ISF in obese versus non-obese …
cefazolin concentrations, but significantly lower unbound cefazolin ISF in obese versus non-obese …
[HTML][HTML] Measurement of soft tissue drug concentrations in morbidly obese and non-obese patients–a prospective, parallel group, open-labeled, controlled, phase IV …
P Simon, D Petroff, C Dorn, L Ehmann, C Kloft… - Contemporary Clinical …, 2019 - Elsevier
… /tazobactam, fosfomcyine, cefazolin, metronidazole and as … /m 2 for obese or between 18.5
and 30 kg/m 2 for non-obese … cut-off 20,000 Da, CMA, Kista, Sweden) were placed into the …
and 30 kg/m 2 for non-obese … cut-off 20,000 Da, CMA, Kista, Sweden) were placed into the …
Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients: a controlled clinical trial
C Dorn, D Petroff, N Neumann, A Kratzer… - Journal of …, 2019 - academic.oup.com
… of surgical patients were only marginally different between obese and non-obese patients,
the drug exposure in subcutaneous tissue was significantly lower in the obese patients. …
the drug exposure in subcutaneous tissue was significantly lower in the obese patients. …
[HTML][HTML] Prophylactic cefazolin dosing and surgical site infections: does the dose matter in obese patients?
… the recommended dose or weight or BMI cut-off values [6, 7]. … of cefazolin may be inadequate
in morbidly obese patients … SSI prevalence between obese and non-obese patients, or …
in morbidly obese patients … SSI prevalence between obese and non-obese patients, or …
[HTML][HTML] Linezolid concentrations in plasma and subcutaneous tissue are reduced in obese patients, resulting in a higher risk of underdosing in critically ill patients: a …
P Simon, D Busse, D Petroff, C Dorn, L Ehmann… - Journal of Clinical …, 2020 - mdpi.com
… , we accrued obese and non-obese patients undergoing … free linezolid concentrations in
soft tissue by microdialysis. … at a subcutaneous target site, in morbidly obese patients and …
soft tissue by microdialysis. … at a subcutaneous target site, in morbidly obese patients and …
Prophylactic cefazolin dosing in women with body mass index> 35 kg· m− 2 undergoing cesarean delivery: a pharmacokinetic study of plasma and interstitial fluid
VA Eley, R Christensen, R Ryan, D Jackson… - Anesthesia & …, 2020 - journals.lww.com
… We used a reduction of AIC for statistical … of cefazolin after 2 hours may be required to be
certain of achieving target concentrations of >2 mg·L −1 in the ISF of subcutaneous tissue in …
certain of achieving target concentrations of >2 mg·L −1 in the ISF of subcutaneous tissue in …
Drug dosing in obese surgical patients
Z Hussain - 2019 - figshare.utas.edu.au
… of SSIs in obese and non-obese patients (BMI ≥ 30kg/m2 and < … the standard 2g dose of
cefazolin preoperatively. A 5-year … of skeletal and subcutaneous tissues in obese compared to …
cefazolin preoperatively. A 5-year … of skeletal and subcutaneous tissues in obese compared to …
[HTML][HTML] Prophylactic cefazolin dosing in obesity—a systematic review
M Coates, A Shield, GM Peterson, Z Hussain - Obesity Surgery, 2022 - Springer
… reduce the efficacy of a standard dose for non-obese … in the cohort with obesity compared to
the non-obese cohort, … g doses in plasma and subcutaneous tissue concentrations and used …
the non-obese cohort, … g doses in plasma and subcutaneous tissue concentrations and used …
[HTML][HTML] Application of a physiologically based pharmacokinetic model to predict cefazolin and cefuroxime disposition in obese pregnant women undergoing …
… lipophilicity of cefuroxime is lower than cefazolin (Log p … cefazolin in non–pregnant, non–obese
subjects as well as in … simulated cefazolin total adipose concentrations in morbidly obese …
subjects as well as in … simulated cefazolin total adipose concentrations in morbidly obese …